HEPATOPROTECTIVE ACTIVITY FROM ETHANOL EXTRACT OF PUGUN TANO’S LEAVE (Curanga fel-terrae (Lour.) Merr.)


Urip Harahap, Marianne Bastian, Sri Yuliasmi, Dadang Irfan Husori, Popi Patilaya, Lia Laila

Abstract


Objective: The aim of this study is to observe the activity of ethanol extract of Curanga fel-terrae leave in preventing the damaged of liver which is induced by high dose of paracetamol.

 

Methods: This research was conducted by using Wistar rat divided into 6 groups. Group 1 was the normal group. Group 2, 3, 4, 5 and 6 received CMC-Na 0.5% (negative control), C. fel-terrae ethanolic extract (CFEE) at the doses of 125, 250 and 500 mg/kg, catechin 2 mg/kg (positive control),respectively during 7 days continued and followed by given paracetamol dose of 2.5g/kg 8 hours after that. Hepatoprotective activity was carried out toward parameter of AST, ALT as well as histopathology of the liver.

 

Results: The results showed that high-dose paracetamol dose of 2.5g/kg bw can cause liver damaged which can be seen by the increasing of the level of AST and ALT compared to the normal group (p<0.05). The usage of three doses of CFEEfor 7 days showed the prevention of the increasing of the level of AST and ALT compared to negative control group (p<0.05). Furthermore, the histopathology study revealed that the three doses of extract could protect the liver.

 

Conclusion: The C. fel-terrae ethanolic extract (CFEE) at the doses of 125, 250 and 500 mg/kg bw which was given for 7 days can prevent the liver from the damage caused by high-dose of paracetamol.

 

Keyword: Curanga fel-terrae (Lour.) Merr., paracetamol, liver, hepatoprotective   


Keywords


Curanga fel-terrae (Lour.) Merr., Paracetamol, Liver, Hepatoprotective.

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About this article

Title

HEPATOPROTECTIVE ACTIVITY FROM ETHANOL EXTRACT OF PUGUN TANO’S LEAVE (Curanga fel-terrae (Lour.) Merr.)

Keywords

Curanga fel-terrae (Lour.) Merr., Paracetamol, Liver, Hepatoprotective.

DOI

10.22159/ajpcr.2017.v10i11.19127

Date

01-11-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 11 November 2017 Page: 78-82

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

47 Views | 67 Downloads

Authors & Affiliations

Urip Harahap
Department of Pharmacology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
Indonesia

Marianne Bastian
Department of Pharmacology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
Indonesia

Sri Yuliasmi
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
Iraq

Dadang Irfan Husori
Department of Pharmacology Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
Indonesia

Popi Patilaya
Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
Indonesia

Lia Laila
Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan 20155, Indonesia.
Indonesia


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