PHYTOCHEMICAL SCREENING AND ANTIDIABETIC ACTIVITY OF DIFFERENT LEAF EXTRACTS FROM LOTUS (NELUMBO NUCIFERA GAERTN.) IN STREPTOZOTOCIN INDUCED MICE


Ruth Mayana Rumanti, Marline Nainggolan, Urip Harahap

Abstract


 

 Objective: The present study is to evaluate the antidiabetic activity of various extract of Lotus (Nelumbo nucifera Gaertn.) leaf using hexane, ethyl acetate, and ethanol organic solvent.

Methods: Standard phytochemical screening method and streptozotocin induced diabetic mice.

Result: The phytochemical screening showed only ethyl acetate of lotus leaf extract contains the flavonoids. The ethyl acetate lotus leaf extract (dose level 150 mg/kg) showed a significant reduction of the blood glucose.

Conclusion: The ethyl acetate extract of lotus leaf (N. nucifera Gaertn.) had the hypoglycemic effect on diabetic induced mice.


Keywords


Lotus, Diabetes mellitus, Antidiabetic, Streptozotocin, Mice.

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About this article

Title

PHYTOCHEMICAL SCREENING AND ANTIDIABETIC ACTIVITY OF DIFFERENT LEAF EXTRACTS FROM LOTUS (NELUMBO NUCIFERA GAERTN.) IN STREPTOZOTOCIN INDUCED MICE

Topics

Biological Pharmacy

Keywords

Lotus, Diabetes mellitus, Antidiabetic, Streptozotocin, Mice.

DOI

10.22159/ajpcr.2017.v10i12.20888

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 190-192

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

14 Views | 35 Downloads

Authors & Affiliations

Ruth Mayana Rumanti
Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
Indonesia

Marline Nainggolan
Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
Indonesia

Urip Harahap
Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
Indonesia


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