EVALUATION OF ANTIANXIETY EFFECT OF DRIED FRUITS OF PRUNUS AMERICANA MARSH
Objective: To evaluate antianxiety effect of dried fruits of Prunus americana Marsh. Family Rosaceae.
Methods: Phytochemical screening was performed on various extracts of the fruits. Elevated plus maze and light/dark choice tests were used for screening of antianxiety activity. Diazepam (2 mg/kg) was used as the standard drug.
Results: Phytochemical screening has shown the presence of various constituents such as flavonoids, carbohydrates, tannins, alkaloids, phenols, and saponins. Different concentrations (100 and 200 mg/kg) of the ethanolic extract of P. americana have shown promising results. Significant antianxiety activity was observed in ethanol extract at the dose of 200 mg/kg in both models.
Conclusion: The present study suggests that ethanolic extract of P. americana contains certain chemical components that are responsible for the antianxiety effect of the fruits of the plant. The plant may be considered for the management of various disorders related to anxiety.
2. Chakraborty A, Amudha P, Geetha M, Singh NS. Evaluation of anxiolytic activity of methanolic extract of Sapindus mukorossi in mice. Int J Pharm Biosci 2010;1:1-8.
3. Yadav YC, Jain A, Deb L. A review: Neuropharmacological screening techniques for pharmaceuticals. Int J Pharm Pharm Sci 2010;2(2):10-4.
4. Rashid F, Ahmed R, Mahmood A, Ahmad Z, Bibi N, Kazmi SU. Flavonoid glycosides from Prunus americana and the antibacterial activity of a crude extract. Arch Pharm Res 2007;30:932-7.
5. Jabeen Q, Aslam N. Review on the pharmacological activities of prunes. J Med Plants Res 2011;5(9):1508-11.
6. Farnsworth NR. Biological and phytochemical screening of plants. J Pharm Sci 1966;55(3):225-76.
7. Malar JT, Gandhi S, Glory, Jothi S, Maheshwari U. Anti-inflammatory potential of Capparis diversifolia wight and Arn leaf extract against carrageenan induced paw edema in rats. Int J Res Ayurveda Pharm 2017;8(1):101-3.
8. Kulkarni SK, Reddy DS. Animal behavioral models for testing antianxiety agents. Methods Find Exp Clin Pharmacol 1996;18(3):219-30.
9. Vogel HG, Vogel WH. Drug Discovery and Evaluation. Springer: Verlag, Heidelberg, Germany; 1997. p. 378-9.
10. Dutt VG, Dhar VJ, Sharma A, Dutt R. Experimental model for antianxiety activity: A review. Pharmacol Online 2011;1:394-404.
11. Nakatani N, Kayano S, Kikuzaki H, Sumino K, Katagiri K, Mitani T. Identification, quantitative determination, and antioxidative activities of chlorogenic acid isomers in prune (Prunus domestica L.). J Agric Food Chem 2000;48(11):5512-6.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.