FORMULATION OF HAJRAL YAHUD PISHTI AND ITS IN VITRO ANTIUROLITHIATIC EFFECT

Authors

  • Chhaya Kumari School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India
  • Dileep Singh Baghel School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India
  • Bimlesh Kumar School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India
  • Saurabh Singh School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India

DOI:

https://doi.org/10.22159/ajpcr.2018.v11i2.23385

Keywords:

Pishti, Hajral yahud, Antiurolithiatic, in vitro, Urolithiasis

Abstract

 Objectives: The objectives of this study were to formulate and analyze the physicochemical properties of hajral yahud pishti and its in vitro evaluation for antiurolithiatic effect.

Methods: Hajral yahud pishti was prepared using chandan arka, nagarmotha arka, and jala (water), respectively, as bhawana dravya. Physicochemical parameters were carried out using standard methods mentioned in official compendium of Ayurveda. In vitro antiurolithiatic activity of the prepared hajral yahud was done on artificially prepared urine.

Results: No significant variation was observed in the physicochemical analysis of all prepared samples in different concentrations, i.e., 100, 200, 400, 800, and 1000 μL of the hajral yahud pishti showed dose-dependent antiurolithiatic activity in prepared artificial urine 1000 μL concentration exhibited 74.47% protection.

Conclusion: The prepared hajral yahud pishti gave protection against urolithiasis.

Author Biography

Chhaya Kumari, School of Pharmaceutical Sciences, Lovely Professional University, Punjab, India

Associate Proffessor and Head of Labs, School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab

References

Ahmed S, Hasan M. Muslim heritage in medicine: A concise review on Greco-Arabic contribution. J Pharmacogn Phytochem 2016;5:273-83.

Rajesh. Study of hasate Kulya (Renal Calculus) with therapeutic evaluation of unani formulation (Sufoof Hajrul Yahud) in its management. Int J Sci Res 2016;5:268-71.

Shastri S. Agnivesha Charaka Samhita. Chikitsa Sthana 26/599. Varanasi: Chaukhamba Bharti Academy; 2006.

Sushruta. Sushruta Samhita. Sutra Sthana 33/126. Varanasi: Chaukhambha Sanskrit Sansthan; 2005.

Sodimbaku V, Pujari L. Urolithiasis-an updated review over genetics, pathophysiology and its clinical management. Int J Pharm Pharm Sci 2014;6:23-31.

Moe OW. Kidney stones: Pathophysiology and medical management. Lancet 2006;367:333-44.

Evan A, Lingeman J, Coe FL, Worcester E. Randall’s plaque: Pathogenesis and role in calcium oxalate nephrolithiasis. Kidney Int 2006;69:1313-8.

Stamatelou KK, Francis ME, Jones CA, Nyberg LM, Curhan GC. Time trends in reported prevalence of kidney stones in the United States: 1976-1994. Kidney Int 2003;63:1817-23.

Mohanty NK, Nayak RL, Patki PS. Safety and efficacy of an ayurvedic formulation cystone in management of ureteric calculi: A prospective randomized placebo controlled study. Am J Pharm Toxicol 2010;5:58-64.

Shanmugapriya J, Kumar SS. A prospective study on quality of life in patients with urinary calculi. Asian J Pharm Clin Res 2017;10:191-3.

Coe FL, Evan A, Worcester E. Kidney stone disease. J Clin Invest 2005;115:2598-608.

Prasad K, Sujatha D, Bharathi K. Herbal drugs in urolithiasis - A review. Phcog Rev 2007;1:175-9.

Parks JH, Coward M, Coe FL. Correspondence between stone composition and urine super saturation in nephrolithiasis. Kidney Int 1997;51:894-900.

Khan SR. Calcium phosphate/calcium oxalate crystal association in urinary stones: Implications for heterogeneous nucleation of calcium oxalate. J Urol 1997;157:376-83.

Mustapha B, Hanane B, Idrissi M, Benramdane Larbi OB, Mustapha D. In vitro effect of acetylsalicylic acid on calcium oxalate crystallization: An approach to antilithiasis. Int J Pharm Pharm Sci 2015;7:329-31.

Aggarwal D, Sharma M, Singla SK. The role of natural antioxidants as potential therapeutic agent in nephrolithiasis. Asian J Pharm Clin Res 2013;6:48-53.

Sayana SB, Khanwelkar CC, Nimmagadda VR, Chavan VR. Antiurolithic activity of aqueous extract of roots of Cissampelos pareira in albino rats. Asian J Pharm Clin Res 2014;7:49-53.

Wahab S. Authentication and quality evaluation of an important ayurvedic drug Averrhoa carambola Linn Leaves. Asian J Pharm Clin Res 2013;6:52-6.

Ravana L. Arkaprakasha. 3rd ed. Varanasi, India: Chaukambha Krishnadas Academy; 2011.

Rahul U, Hussain G, Ganti BY. Pharmaceutical review of Arka Kalpana. Int Ayurvedic Med J 2014;2:1113-20.

Gaud SD, Nighantu S. Reprinted edition Varanasi: Chaukhamba Vidyabhawan; 2002. p. 431, 141, 87.

Trikamji Acharya VY. Sidhiyog Sangrah. Ch. 18. Nagpur, India: Sh. Baidyanath Ayurveda Bhawan Limited 2003. p. 99.

Krishnanad S. Rasatantra Sara Va Siddha Prayoga Samraha 16th ed. Ajmer, India: Krishan Gopal Ayurveda Bhawan; 2003. p. 219.

Zhang J, Wider B, Shang H, Li X, Ernst E. Quality of herbal medicines: Challenges and solutions. Complement Ther Med 2012;20:100-6.

Patra KC, Kumar KJ, Suresh P. Standardization of a polyherbal Siddha formulation, Amukkara Choornam. Indian J Tradit Knowl 2009;8:449-e52.

Lohar DR. Protocol for testing of Ayurvedic, Siddha and Unani medicines. Ghaziabad: Pharmacopoeial Laboratory for Indian Medicine, AYUSH. Ministry of Health and Family Welfare. Government of India; 2011. p. 25.

Satheesh NV, Upadhyaya K, Bisht A. Phytochemical screening and standardization of polyherbal formulation for dyslipidemia. Int J Pharm Pharm Sci 2011;3:235e8, 17,18.

Thakkar R, Baghel DS, Singh S. Physicochemical screening of Godanti Bhasma: An effort to pharmaceutical standardisation. J Pharm Res 2017;11:887-94.

Sharma S, Baghel DS, Singh S, Singh SK. Dosage form development and preliminary physicochemical characterization of Trikantakadi Kvatha. Asian J Pharm Clin Res 2017;2017:52-6.

Sharma R, Amin H, Galib, Prajapati PK. Validation of standard manufacturing procedure of Guduchi satva (aqueous extract of Tinospora cordifolia (Willd.) Miers) and its tablets. Anc Sci Life 2013;33:27-e34.

Jain V, Swarnlata S, Saraf S. Spectrophotometric determination of piperinein trikatu churna: An ayurvedic formulation. Asian J Chem 2007;19:5331-5.

Almeida RM, Pantano CG. Structural investigation of silica gel films by infrared spectroscopy. J Appl Phys 1990;68:4225-32.

Ahmed S, Hasan MM, Mahmood ZA. In vitro urolithiasis models: An evaluation of prophylactic management against kidney stones. J Pharmacogn Phytochem 2016;5:28-35.

Rajeshwari P, Rajeswari G, Jabbirulla S, Vardhan IV. Evaluation of in vitro anti-urolithiasis activity of Convolvulus arvensis. Int J Pharm Pharm Sci 2013;5:599-601.

Agarwal K, Varma R. In-vitro Calcium oxalate crystallization inhibition by Achyranthes aspera L. and Bryophyllum pinnatum Lam. Br J Pharm Res 2015;5:146-52.

Rupam VP, Khan ND, Khan ZH, Mular SM. Study on in vitro antiurolithiatic activity of Bryophyllum pinnatum and Ocimum gratissimum leaves. Biosci Discov 2017;8:290-4.

Priya K, Gazala H, Reshma SM, Govindan ND. Pharmaceutico analytical study of Vacha arka. J Biol Sci Opin 2013;1:314-6.

Atmani F, Khan SR. Effects of an extract from Herniaria hirsuta on calcium oxalate crystallization in vitro. BJU Int 2000;85:621.

Kok DJ, Papapoulos SE, Blomen LJ, Bijvoet OL. Modulation of calcium oxalate monohydrate crystallization kinetics in vitro. Kidney Int 1988;34:346-50.

Rao GD. Practical Pharmaceutical Analysis. 1st ed. Delhi: Publisher Birla publications (Regd) Pvt. Ltd.; 2007. p. 137-8.

Published

2018-02-01

How to Cite

Kumari, C., D. S. Baghel, B. Kumar, and S. Singh. “FORMULATION OF HAJRAL YAHUD PISHTI AND ITS IN VITRO ANTIUROLITHIATIC EFFECT”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 2, Feb. 2018, pp. 370-8, doi:10.22159/ajpcr.2018.v11i2.23385.

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