IMPACT OF PARTICLE SIZE OF KWATHYADRAVYA (DECOCTION POWDER) IN THE PREPARATION OF PHALTRIKADI KWATH
Â Objectives: The study was aimed to investigate the effects of particle size, vessel used, and extraction time in the preparation of Phaltrikadi kwath.
Methods: The particle size of Kwath dravya (solute) was cut into the size of 0.5 cm, 1 cm, 1.5 cm, 2 cm, and coarse powder (pass 60#). The ratios of solvent (water) were 16 times of solute and boiling was done till 1/4th part of the solvent was remain. The provided extraction time was also varied 5.5 to 6 h at temperature range 23Câ€“90Â°C. Phaltrikadi kwath was prepared as per formula mentioned in â€œSharngadhar samhitaâ€ Madhyam khand 2/77.
Results: Total 15 samples of Phaltrikadi kwath were prepared and analyzed for physicochemical and phytochemical parameters, from obtained value, it was confirmed that extraction procedure with varied particle size significantly affected the yield of active pharmaceutical ingredients in prepared Phaltrikadi kwath. Coarse particle sizes can produce a higher yield. Moreover, a longer extraction time produces a higher yield.
Conclusion: Kwath (decoction) prepared by particle size 1.5 cm and 2.0 cm may be more therapeutically effective, as it has total solid content more than 6%, it proves that â€œYavakutaâ€ phenomena of Ayurvedic classics.
2. Thakkur CG. Introduction to Ayurveda: Basic Indian Medicine. 2nd ed. Printed by J.S. Khamesra for G. Claridge & Co. Ltd. Jamnagar: Bombay and Published by Shri K.P. Shah. Hon. Secretory. Gulabkunverba Ayurvedic Society; 1976.
3. Ramchandra RK. Bhaishajya Kalpana Vijnanam. 1st ed. Varanasi: Chaukhambha Sanskrit Bhavan; 1998.
4. Shobha GH. A Text Book of Bhaishajya Kalpana. 1st ed. Bangalore: IBH Prakashan; 2000.
5. Das SG. Bhaishajya Ratnaval. 14th ed. Varanasi: Chaukhamba Sanskrit Samsthan; 2001.
6. Pandit SP. Sharandhar Samhita. Commentary of Adhmalâ€™s Dipika and Kashiramâ€™s Gudharthdipika. 5th ed. Varansi: Madhyam Khanda, Chakhumba Orientalia; 2002.
7. Karan SR, Vaidya BD. Agnivesaâ€™s Caraka Samhita. 3rd ed. Varanasi: Chowkhamba Sanskrit Series Office; 1992.
8. Samhita S. Commentary by Dr. Bhaskar Govind Ghanekar. New Delhi: Meherchand Lachamandas Publications; 2002.
9. Hridaya A. Commentaries â€œSarwanga Sundaraâ€ of Arunadutta and â€œAyurveda Rasayanaâ€ of Hemadri. Varanasi: Chaukhambha Orientalia; 2002.
10. Vagbhata M. Ashtanga Samgraha. Edited with â€˜Sarojâ€™ Hindi commentary by Dr. Ravi Dutt Tripathi. Delhi: Chaukhambha Sanskrit Pratishthan; 1996.
11. Sangraha AS. ???. 29th ed. Nagpur: Published by Shri Baidhyanath Ayurved Bhawan Pvt., Ltd.; 2004.
12. Carter SJ. Cooper and Gunn; s. Dispensing for Pharmaceutical Students. 12th ed. Delhi: CBS Publishers and Distributors; 1987.
13. Liebermon HA, Kaning JL. Lachmon Lean. The Theory and Practice of Industrial Pharmacy. 3rd ed. Bombay: Varghese Publishing House; 1987.
14. Mittal BM. A Text Book of Pharmaceutical Formulation. 6th ed. Delhi: Vallabha Prakashan; 1994.
15. Gennaro AE. Remingtonâ€™s. The Science and Practice of Pharmacy. 20th ed. Vol. I and II. Easton PA: Mack Publishing Company; 2000.
16. Bhanu PS, Zafar R, Panwar R. Herbal drug standardization. Indian Pharm 2005;4:19-22.
17. Patel PM, Patel NM, Goyal RK. Quality control of herbal products. Indian Pharm 2006;5:26-30.
18. Anonymous. Regional Research Laboratory. Vol. II. Jammu Tawi: Regional Research Laboratory Council of Scientific and Industrial Research; 1999.
19. Gupta AK. Quality Standards of Indian Medicinal Plants. Vol. I. India: Indian Council of Medical Research; 2003.
20. Ahmad RV, Sharma RK. Evaluation of Drug for Standardization. Proceedings of WHO Training cum- Workshop. Pharmaceutical Lab for Indian Medicine. Ghaziabad: Ministry of Health and Family Welfare. Government of India; 2001.
21. Harbone JB. Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis. London: Chapman and Hall Ltd.; 1984.
22. Anonymous. The Ayurvedic Formulary of India (AFI). Part I. 2nd Revised Englished. New Delhi: Government of India. Ministry of Health and Family Welfare. Department of Indian System of Medicine and Homeopathy; 2003.
23. Baxi AJ, Shukla VJ. Bhatt UB. Methods of Qualitative Testing of some Ayurvedic Formulations. Jamnagar: Gujarat Ayurved University; 2001.
24. Keerthiga M, Anand SP. Physicochemical, preliminary phytochemical analysis and antibacterial activity against clinical pathogens of medicinally important orchid Geodorum densiflorum (Lam) Schltr. Int J Pharm Pharm Sci 2014;6:558-61.
25. Prakasia PP, Nair AS. Evaluation of in vitro antioxidant potential of the total crude alkaloid extract of Glycosmis pentaphylla (Retz.) Correa leaves. Int J Pharm Pharm Sci 2016;8:3.