THE EFFECT OF ACUTE CONSUMPTION OF HYDROLYZED OILS ON SWIMMING CAPACITY ENDURANCE OF MICE (MUS MUSCULUS)

  • Jansen Silalahi Department of Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Wina A Barus Department of Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Dwi R Anggraini Department of Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Aminah Dalimunthe Department of Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Yosy C E Silalahi Department of Pharmacy, Faculty of Pharmacy and Health Sciences, Universitas Sari Mutiara Indonesia Medan, Indonesia.

Abstract

Objective: The aim of this study was to investigate the effect of hydrolyzed oils of different fatty acids composition on swimming capacity of mice.

Methods:The oils used were Virgin Coconut oil (VCO) and Palm Kernel oil (PKO) as medium chain triglyceride (MCT) oils, Palm oil and Corn oil as long chain triglyceride (LCT) oils. Hydrolysis of the oil was performed with Rhizomucor miehei lipase enzyme. The mice were acclimatized and tested motoric to select the mice and divided into twenty groups, each group consisted of 5 mice. Each oil in the experiment were 0.1 ml, 0.2 ml, 0.4 ml/ 20 g BW, positive control was caffeine 13 mg/kg bw. Then, the mice were placed in a glass aquarium. Then swimming capacty endurance was measured.

Results:.Non-hydrolyzed oils with dose of 0.1ml significantly induced swimming capacity of mice compared with negative control (distilled water) from 184.8 increased to 248.0 seconds by MCT oil, to 239.8 seconds by unsaturated LCT oil and to 214.8 seconds by saturated LCT oil. The hydrolyzed oils increased swimming capacity ± 65% by hydrolyzed MCT oils, ±54% by hydrolyzed unsaturated LCT oil and 21% by hydrolyzed saturated LCT oil. The hydrolyzed corn oil at high dose (0.4ml) was more effective to increase swimming capacity than saturated MCT (VCO and PKO) and LCT oil (palm oil).

Conclusion:The results suggest that hydrolyzed MCT and LCT oils are more effective to increase swimming capacity than non-hydrolyzed.

Keywords: Coconut oil, palm kernel oil, palm oil, corn oil, hydrolysis, swimming capacity

Author Biography

Jansen Silalahi, Department of Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
Department of Pharmaceutical Chemistry

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Silalahi, J., W. A Barus, D. R. Anggraini, A. Dalimunthe, and Y. C. E Silalahi. “THE EFFECT OF ACUTE CONSUMPTION OF HYDROLYZED OILS ON SWIMMING CAPACITY ENDURANCE OF MICE (MUS MUSCULUS)”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 12, no. 1, Jan. 2019, pp. 512-5, doi:10.22159/ajpcr.2019.v12i1.29824.
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