CORRELATION BETWEEN LOCUS POLYMORPHISM OF COL11A1 GENE AND OCULAR BIOMETRY IN ACUTE AND CHRONIC PRIMARY ANGLE CLOSURE GLAUCOMA
Objective: The objective of this study is to analyze the correlation between locus polymorphisms of genetics variants of rs3753841 (COL11A1) and ocular biometry, including anterior chamber depth (ACD), axial length (AL), and lens thickness (LT) in acute and chronic primary angle-closure glaucoma (PACG) patients.
Methods: A total of 50 patients consisting of 25 acute PACG and 25 chronic PACG patients were included in this study. Ocular biometric parameters including anterior ACD, AL, and LT measurement were performed in all subjects using A-scan biometry. DNA isolation from blood samples was performed using PCR sequencing for genotyping locus polymorphisms of rs3753841 (COL11A1).
Results: Mean ACD was shallower (2.40±0.40 mm), mean AL was shorter (21.86±1.31 mm), and mean LT was thicker (5.01±0.49 mm) in acute PACG compared to chronic PACG group, yet with no significant difference (p>0.05). We found a statistically significant difference of rs3753841 (COL11A1) polymorphism, with heterozygous mutant was mostly found in chronic PACG and homozygous mutant was mostly found in acute PACG patients (p<0.05). Significant correlations were also found between the locus polymorphism and ocular biometry (ACD and AL) in chronic PACG (p<0.05).
Conclusion: We confirmed the polymorphisms of rs3753841 (COL11A1) in both groups and its significant correlation with ocular biometry (ACD and AL) in chronic PACG.
2. Ilahi F, Liyanti R. Quality of life assessment glaucoma patients based on glaucoma symptom scale and glaucoma quality of life-15 score at M. Djamil Hospital Padang. Ophthalmol Indones 2017;43:57-62.
3. Razeghinejad MR, Banifatemi M. Ocular biometry in angle closure. J Ophthalmic Vis Res 2013;8:17-24.
4. Vithana EN, Khor CC, Qiao C, Nongpiur ME, George R, Chen LJ, et al. Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. Nat Genet 2013;44:1142-6.
5. Awadalla MS, Thapa SS, Hewitt AW, Burdon KP, Craig JE. Association of genetic variants with primary angle closure glaucoma in two different populations. PLoS One 2013;8:e67903.
6. Chen Y, Chen X, Wang L, Hughes G, Qian S, Sun X. Extended association study of PLEKHA7 and COL11A1 With primary angle closure glaucoma in a han Chinese population. Invest Ophthalmol Vis Sci 2014;55:3797-802.
7. Sun X, Dai Y, Chen Y, Yu D, Cringle SJ, Chen J, et al. Primary angle closure glaucoma: What we know and what we don’t know. Prog Retin Eye Res 2016;46:26-45.
8. Stamper RL, Lieberman MF, Drake MV. Primary angle closure glaucoma. In: Becker-Shaffer’s Diagnosis and Therapy of the Glaucomas. 8th ed. USA: Elsevier; 2009. p. 196-214.
9. Skuta GL, Cantor LB, Cioffi GA. Angle-closure glaucoma. In: Glaucoma. San Fransisco: American Academy of Ophthalmology; 2014. p. 109-37.
10. National Health and Medical Research Council. Angle closure glaucoma. In: Guidelines for the Screening, Prognosis, Diagnosis, Management, and Prevention of Glaucoma. Canberra: National Health and Medical Research Council Guidelines; 2010. p. 44-5.
11. Wan Y, Li S, Gao Y, Tang L, Cao W, Sun X. COL11A1 polymorphisms are associated with primary angle-closure glaucoma severity. J Ophthalmol 2019;2019:2604386.
12. Duvesh R, Verma A, Venkatesh R, Kavitha S, Ramulu PY, Wojciechowski R, et al. Association study in a south indian population supports Rs1015213 as a risk factor for primary angle closure. Invest Ophthalmol Vis Sci 2013;54:5624-8.
13. Lowe RF. Aetiology of the anatomical basis for primary angle-closure glaucoma. Biometrical comparisons between normal eyes and eyes with primary angle-closure glaucoma. Br J Ophthalmol 1970;54:165-9.
14. Hamzeh N, Moghimi S, Latifi G, Mohammadi M, Khatibi N, Lin SC. Lens thickness assessment: Anterior segment optical coherence tomography versus A-scan ultrasonography. Int J Ophthalmol 2014;8:1151-5.
15. Thapa SS, Paudyal I, Khanal S, Paudel N, van Rens GH. Comparison of axial lengths in occludable angle and angle-closure glaucoma--the bhaktapur glaucoma study. Optom Vis Sci 2011;88:150-4.
16. George R, Paul PG, Baskaran M, Ramesh SV, Raju P, Arvind H, et al. Ocular biometry in occludable angles and angle closure glaucoma: A population based survey. Br J Ophthalmol 2003;87:399-402.
17. Bourne RR, Sørensen KE, Klauber A, Foster PJ, Johnson GJ, Alsbirk PH. Glaucoma in east greenlandic inuit--a population survey in ittoqqortoormiit (scoresbysund). Acta Ophthalmol Scand 2001;79:462-7.
18. Nolan WP, Baasanhu J, Undraa A, Uranchimeg D, Ganzorig S, Johnson GJ. Screening for primary angle closure in Mongolia: A randomised controlled trial to determine whether screening and prophylactic treatment will reduce the incidence of primary angle closure glaucoma in an East Asian population. Br J Ophthalmol 2003;81:271-4.
19. Feng MT, Belin MW, Grewal SPS, Yan W, Shaheen MS, Mcghee C, et al. Anterior chamber depth in normal subjects by rotating scheimpflug imaging. Saudi J Ophthalmol 2011;25:255-9.
20. Tarongoy P, Ho CL, Walton DS. Angle-closure glaucoma: The role of the lens in the pathogenesis, prevention, and treatment. Surv Ophthalmol 2009;54:211-25.
21. Shi H, Zhu R, Hu N, Shi J, Zhang J, Jiang L, et al. An extensive replication study on three new susceptibility loci of primary angle closure glaucoma in Han Chinese: Jiangsu Eye Study. J Ophthalmol 2013;2013:641596.
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