THE ANTIBACTERIAL POTENTIAL OF N-ACETYLCYSTEINE AS AN ENDODONTIC IRRIGANT ON THE CLINICAL ISOLATES OF THE ENTEROCOCCUS FAECALIS BIOFILM


Ridzki Ridhalaksani, Kamizar Nazar, Nila Kesuma Djauharie, Ratna Meidyawati, Dewa Ayu Npa

Abstract


Objective: The aim of this study was to evaluate the antibacterial potential of NAC as an endodontic irrigant on the clinical isolates of the Enterococcus faecalis biofilm.

Methods: NAC with a pH of 2.5 and 11 (NAC pH 2.5 and NAC pH 11, respectively) were exposed to clinical isolates of E. faecalis biofilms for 1 min. The NAC samples were compared to 2% chlorhexidine (CHX), which is commonly used as an irrigant in persistent infections. The antibacterial potential of these irrigants was evaluated by comparing the bacterial count of the E. faecalis colonies after they were exposed to the irrigants.

Results: The NAC pH 2.5 test group showed a reduction in the E. faecalis colonies, but this reduction was not statistically significant when compared to the 2% CHX group results. The NAC pH 11 test group showed the greatest reduction in bacterial colonies, and this reduction was statistically significant when compared to the NAC pH 2.5 and 2% CHX groups’ results.

Conclusion: NAC pH 11 has antibacterial potential on the clinical isolates of E. faecalis biofilms.


Keywords


Enterococcus faecalis, Biofilm, Irrigation, N-acetylcystein

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About this article

Title

THE ANTIBACTERIAL POTENTIAL OF N-ACETYLCYSTEINE AS AN ENDODONTIC IRRIGANT ON THE CLINICAL ISOLATES OF THE ENTEROCOCCUS FAECALIS BIOFILM

Keywords

Enterococcus faecalis, Biofilm, Irrigation, N-acetylcystein

DOI

10.22159/ijap.2017.v9s2.05

Date

01-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue 2 (Dec.), 2017 Page: 17-19

Online ISSN

0975-7058

Statistics

121 Views | 169 Downloads

Authors & Affiliations

Ridzki Ridhalaksani
Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Kamizar Nazar
Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
Indonesia

Nila Kesuma Djauharie
Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Ratna Meidyawati
Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Dewa Ayu Npa
Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia


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