ANTIFUNGAL EFFECTS OF ALOE VERA IRRIGANT ON CANDIDA ALBICANS BIOFILM
Objective: Candida albicans tolerates unfavorable environmental conditions by forming biofilms, which can cause problems following endodontic
treatments. C. albicans is the most common fungus found in failed root canals. Using natural irrigants with good antifungal properties for use as
synthetic irrigant alternatives during root canal cleaning and shaping is very important. This study aimed to analyze the effects of Aloe vera on
C. albicans biofilm.
Methods: C. albicans biofilm was divided into the following five groups: Group I, no treatment (control group); Groups II, III, and IV, A. vera with a
concentration of 100%, 75%, and 50%, respectively; and Group V, Ethylenediaminetetraacetic acid (EDTA) 17%.
Results: The average biofilm colony count for C. albicans for the A. vera 100%, 75%, and 50% groups was higher than that for the EDTA 17% group
but lower than that for the control group.
Conclusion: A. vera has antifungal effects on C. albicans biofilm, with the greatest effect occurring at 75% concentration.
infection. Res Rev 2014;2014:1.
2. Torabinejade M, Walton RE. Endodontics Principles and Practice.
5th ed. Missouri: Elsevier.
3. Waltimo TM, Sen BH, Meurman JH, Ørstavik D, Haapasalo MP. Yeast
in apical periodontitis. Crit Rev Oral Biol Med 2003;14:128-37.
4. Sureshchandra B, Arun K. Antibacterial Efficacy of Aloe vera
Extract on Resistantantimicrobial Strains in Endodontics. Mangalore:
Department of Conservative Dentistry and Endodontics, A.J. Institute
of Dental Sciences.
5. Waltimo TM, Haapasalo M, Zehnder M, Meyer J. Clinical aspect
related to endodontic yeast infections. Endod Top 2004;9:66-78.
6. Sitara U, Hassan N, Naseem J. Anti-fungal activity of Aloe vera gel
against plant pathogenic fungi. Pak J Bot 2011;43:2231-3.
7. Doddanna SJ, Patel S, Sundarrao MA, Veerabhadrappa RS.
Antimicrobial activity of plant extracts on C. albicans: An in vitro
study. Indian J Dent Res 2013;24:401-5.
8. Jose J, Krishnamma S, Peedikayil F, Aman S, Tomy N, Mariodan JP.
Comparative evaluation of antimicrobial activity of qmix, 2.5% sodium
hypochlorite, 2% chlorhexidine, guava leaf extract and aloevera extract
against Enterococcus faecalis and C. albicans–An in-vitro study. J Clin
Diagn Res 2016;10:ZC20-3.
9. Hargreaves K, Berman L. Cohen’s Pathways of the Pulp. 11th ed.
10. Ruddle CF. Endodontic Triad for Success: The Role of Minimally
Invasive Technology; 2015. Available from: http://www.endoruddle.
11. Sari FE. Minimum Inhibitory Concentration and Concentration Kill
Minimal Aloe vera Leaf Extract Against C. albicans which is Isolated
from the Oral Cavity Patient with HIV and C. albicans Strains ATCC
10231 [In Indonesia]. Jakarta: Fakultas Kedokteran Gigi Universitas
12. Stanley MC, Ifeanyi OE, Eziokwu OG. Antimicrobial effects of
Aloe vera on some human pathogens. Int J Curr Microbiol Appl Sci
13. Siqueira JR. Aetiology of root canal treatment failure: Why well-treated
teeth can fail. Int Endod J 2001;34:1-10.
14. Sen BH, Piskin B, Demirici T. Observation of bacteria and fungi in
infected root c canals and dentinal tubules by SEM. Endond Dent
15. Sudarshan R, Annigeri RG, Vijayabala GS. Aloe vera in dentistry.
Indian J Stomatol 2013;4:45-7.
16. Sujatha G, Kumar GS, Muruganandan J, Prasad TS. Aloe vera in
dentistry. J Clin Diagn Res 2014;8:Z101-2.
17. Chhina S, Singh A, Menon I, Singh R, Sharma A, Aggarwal V.
A randomized clinical study for comparative evaluationof Aloe vera
and 0.2% chlorhexidine gluconatemouthwash efficacy on de-novo
plaque formation. J Int Soc Preven Community Dent 2016;6:251-5.
This work is licensed under a Creative Commons Attribution 4.0 International License.