• Herman Suryadi Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
  • Faatichatun Naja Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.
  • Yahdiana Harahap Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia.


Objective: The purpose of this study was to develop sensitive, selective, and valid methods for the detection of bisphenol A (BPA) contamination in
beverage samples using gas chromatography (GC)-flame ionization.
Methods: The optimized analysis system employed a long HP-1 capillary column (30 m, inner diameter 0.25 mm, film thickness 0.25 μm), gradient
column temperature (150°C–260°C at 10°C/min), and nitrogen as a carrier gas (1 mL/min). Samples were prepared for analysis using ethyl acetate
as the extraction solvent.
Results: This method yielded a linearity coefficient of 0.9998, while the limit of detection (LOD) and limit of quantitation (LOQ) were 0.287 μg/mL and
0.956 μg/mL, respectively. All validation parameters, including linearity, selectivity, accuracy, precision, LOD, and LOQ, meet recognized acceptability
criteria. Contamination analysis showed that one of the three beverage brands tested contained 2.4090 μg/mL BPA, and contamination was even
higher after heating.
Conclusion: BPA contamination may occur in canned beverages, especially under improper storage conditions. This GC-based BPA detection system
may be useful for the detection of BPA contamination in consumer beverages.

Keywords: Bisphenol A, Gas chromatography, Contamination analysis, Validation, Canned beverages.


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How to Cite
Suryadi, H., Naja, F., & Harahap, Y. (2018). DETECTION OF BISPHENOL A CONTAMINATION IN CANNED CARBONATED BEVERAGES BY GAS CHROMATOGRAPHY. International Journal of Applied Pharmaceutics, 10(1), 116-119.
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