EFFECTS OF ODONTOCEM AND MINERAL TRIOXIDE AGGREGATE-ANGELUS TOXICITY ON FIBROBLAST VIABILITY

  • DEWI SRI KESUMAWATI Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • ANGGRAINI MARGONO Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia
  • ENDANG SUPRASTIWI Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia

Abstract

Objective: Mineral trioxide aggregate (MTA) is proven to be biocompatible and is used for pulp capping treatment. Odontocem, calcium silicate-based
cement similar to MTA with the addition of a steroid, has recently been developed and to compare the effects of Odontocem and MTA-Angelus toxicity
on fibroblast cell viability.
Methods: Fibroblast cells from embryonated chicken eggs were immersed in Odontocem or MTA-Angelus solution for 24 and 72 h. Cell viability was
analyzed by Microculture Tetrazolium (MTT) 3-(4,5-dimethylthiazol-2- yl)2,5-diphenyltetrazolium bromide assay.
Results: After 24 h, the Odontocem and MTA-Angelus groups showed significantly lower viability (p<0.05) compared with controls. After 72 h, cell
viability was significantly higher in the Odontocem and MTA-Angelus groups. However, there was no significant difference between the Odontocem
and MTA-Angelus groups.
Conclusions: Odontocem and MTA-Angelus have low toxicity for dental applications.

Keywords: Fibroblast cells, Toxicity, Odontocem, Mineral Trioxide Aggregate

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KESUMAWATI, D. S., MARGONO, A., & SUPRASTIWI, E. (2019). EFFECTS OF ODONTOCEM AND MINERAL TRIOXIDE AGGREGATE-ANGELUS TOXICITY ON FIBROBLAST VIABILITY. International Journal of Applied Pharmaceutics, 11(1), 32-34. https://doi.org/10.22159/ijap.2019.v11s1.AR158
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