EFFECT OF POLYMER-INDUCED LIQUID PRECURSOR PROCESS CONTAINING POLYASPARTIC ACID ON INTRAFIBRILLAR DENTIN REMINERALIZATION (MICRO-COMPUTED TOMOGRAPHY ANALYSIS)

  • NORMA AVANTI Conservative Dentistry Residency Program, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • NILAKESUMA DJAUHARIE Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • ANGGRAINI MARGONO Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • RATNA MEIDYAWATI Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • CUT THYSA Conservative Dentistry Residency Program, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.

Abstract

Objective: Caries treatment can be performed by minimal intervention, i.e., by removing the infected dentin and leaving the affected dentin and then
inducing remineralization in the affected dentin. The affected dentin still consists of collagen cross bonds. Polymer-induced liquid precursor process
is a guided tissue remineralization method that aims to remineralize intrafibrillar and extrafibrillar dentin by adding polymers that are similar to
non-collagen protein. One of the non-collagen protein analog materials is polyaspartic acid. The aim of this study was to evaluate the remineralization
of dentin on the demineralized dentin surface after immersed in remineralization solutions containing polyaspartic acid as a non-collagen protein
analog.
Methods: Human premolar teeth extracted for orthodontic purposes were divided into four groups, namely, one control and three treatment groups.
Teeth in the control group were immersed only in the demineralization solution containing acetate buffer (pH 5.0, 66 h). Teeth in the three treatment
groups were immersed in acetate buffer (pH 5.0, 66 h) and then continue to immersed in the remineralization solution containing polyaspartic acid
for 3, 7, and 14 days. Remineralization was evaluated by micro-CT.
Results: Remineralization appeared on the demineralized dentin surface, characterized by an increase in the grayscale index, after immersion in
the remineralization solution containing polyaspartic acid. Significant differences were observed in the mean grayscale index values among the four
groups.
Conclusion: Polyaspartic acid has the potential to induce dentin remineralization.

Keywords: Polyaspartic acid, Polymer-induced liquid precursor process, Non-collagen protein analog, Dentin remineralization

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AVANTI, N., DJAUHARIE, N., MARGONO, A., MEIDYAWATI, R., & THYSA, C. (2020). EFFECT OF POLYMER-INDUCED LIQUID PRECURSOR PROCESS CONTAINING POLYASPARTIC ACID ON INTRAFIBRILLAR DENTIN REMINERALIZATION (MICRO-COMPUTED TOMOGRAPHY ANALYSIS). International Journal of Applied Pharmaceutics, 12(2), 41-44. https://doi.org/10.22159/ijap.2020.v12s2.OP-45
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