REVIEW: FAST DISSOLVING TABLET


Aher Smita S., Saudagar R. B., Shinde Mayuri S.

Abstract


Fast dissolving tablets is one of the most widely accepted dosage forms and also most popular dosage form, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Some solid dosage forms like tablets and capsules are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitations like the first-pass metabolism. Fast dissolving tablets are one of them. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. Some tablets are designed to dissolve fastly in saliva, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate.


Keywords


Fast Dissolving Drug Delivery System, Superdisintegrants, Advantages of FDT, Patented Technology

| PDF | HTML |

References


Gupta A, Mishra AK, Bansal P, Singh R. Recent trends of fast dissolving tablets–an overview of formulation technology. Int J Pharm Biol 2010;1:1-10.

Goel H, Rai P, Rana V, Tiwari AK. Orally disintegrating system: innovation information and technology. Recent Pat Drug Delivery Formulation 2008;2:258-74.

Siddiqui N, Garg G, Sharma PK. Fast dissolving tablets: preparation, characterization and evaluation: an overview. Int J Pharm Sci Rev Res 2010;4:287-96.

Nautiyal U, Singh S, Singh R, Gopal, Kakar S. Fast dissolving tablets as a novel boon: a review. J Pharm Chem Biol Sci 2014;2:25-6.

Hannan PA, Khan JA, Khan A, Safiullah S. Oral dispersible systems: a new approach in drug delivery system. Indian J Pharm Sci 2016;78:2-7.

Abdulrahman ZS, Patel MR, Patel KR. A review on immediate release tablet. Int J Univers Pharm Bio Sci 2014;3:93-113.

Mishra US, Prajapati SK, Bhardwaj P. A review on formulation and evaluation for mouth dissolving tablet. World J Pharm Pharm Sci 2014;8:1778-810.

Ahmed IS, Nafadi MM, Fatahalla FA. Formulation of a fast-dissolving ketoprofen tablet using freeze-drying in blister technique. Drug Dev Ind Pharm 2006;32:437-42.

Amidon GL, Lennernas H, Shah VP, Crison JR. The theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 1995;12:413-20.

Gupta DK, Bajpai M, Chatterjee DP. Fast mouth is dissolving disintegrating tablet and patient counselling points for FDDT review. Int J Res Dev Pharm Life Sci 2014;3:949-58.

Nautiyal U, Singh S, Singh R, Gopal, Kakar S. Fast dissolving tablets as a novel boon: a review. J Pharm Chem Biol Sci 2014;5:25-6.

Sharma S. New generation of the tablet: fast dissolving tablet. Latest Rev Pharma Info Net 2008. p. 6.

Kumari S, Visht S, Sharma PK, Yadav RK. Fast dissolving drug delivery system: a review article. J Pharm Res 2010;3:1444-9.

Kumaresan C. Orally disintegrating tablet-mouth dissolving, sweet taste and target release profile. Pharm Rev 2008;6:1.

Kuchekar BS, Badha AC, Mahajan HS. Mouth dissolving tablets: a novel drug delivery system. Pharmatimes 2003;35:7-9.

Patel TS, Sengupta M. Fast dissolving tablet technology. World J Pharm Sci 2013;2:485-508.

Khan AB, Tripuraneni A. Fast dissolving tablets–a novel approach in drug delivery. Rguhs J Pharm Sci 2014;2:17-6.

Gupta A, Mittal A, Jha KK. Fast dissolving tablet-a review. Pharm Innovation 2012;1:1-7.

Gupta A, Mishra AK, Gupta V, Bansal P, Singh R, Singh AK. Recent trends of fast dissolving tablet-an overview of formulation technology. Int J Pharma Biol Arch 2010;1:1–10.

Shukla D, Chakraborty S, Singh S, Mishra B. Mouth dissolving tablets i: an overview of formulation technology. Sci Pharm 2009;77:309–26.

Basu B, Bagadiya A, Makwana S, Vora V, Batt D, Dharamsi A. Formulation and evaluation of fast dissolving tablets of cinnarizine using super disintegrant blends and subliming material. J Adv Pharma Tech Res 2011;2:266-73.

Bircan Y, Comoglu T. Formulation technologies of orally fast disintegrating tablets. Marmara Pharm J 2012;16:77-81.

Sharma R, Rajput M, Prakash P, Sharma S. Fast dissolving drug delivery system: a review. Int Res J Pharm 2011;2:21-9.

Badguja BP, Mundada AS. The technologies used for developing orally disintegrating tablets: a review. Acta Pharm 2011;61:117–39.

Nagar P, Singh K, Chauhan I, Verma M, Yasir M, Khan A, et al. Orally disintegrating tablets: formulation, preparation techniques and evaluation. J Appl Pharma Sci 2011;1:35-45.

Ito A, Sugihara M. Development of oral dosage forms for elderly patients: use of agar as the base of rapidly disintegrating oral tablets. Chem Pharm Bull 1996;44:2132-6.

Gauri S, Kumar G. Fast dissolving drug delivery and its technologies. Pharma Innovation 2012;1:34-9.

Nagar P, Singh K, Chauhan I, Verma M, Yasir M, Khan A. Orally disintegrating tablets: formulation, preparation techniques and evaluation. J Appl Pharma Sci 2011;1:35-45.

Puttalingaiah L, Kavitha K, Mani TT. Fast disintegrating tablets: an overview of formulation, technology and evaluation. Res J Pharma Biol Chem Sci 2011;2:589-601.

Keshari R, Bharkatiya M, Rathore KS, Shyama S, Kumar, Sirvi G, et al. Fast disolving tablet drug delivery system-anoverview. Int J Pharm 2015;5:577-89.

Nautiyal U, Singh S, Singh R, Gopal, Kakar S. Fast dissolving tablets as a novel boon: a review. J Pharm Chem Biol Sci 2014;2:5-26.

Pagar R, Ahirrao S, Yallatikar T, Wagh M. Review on orodispersible tablets. Int J Res Dev Pharm Life Sci 2014;3:949-58.

Gupta DK, Bajpai M, Chatterjee DP. Fast mouth is dissolving disintegrating tablet and patient counselling points for FDDT review. Int J Res Dev Pharm Life Sci 2014;3:949-58.

Acosta C, Tabare R, Ouali A. US patent; 1998;5:807.

Khan AB, Tripuraneni A. Fast dissolving tablets–a novel approach in drug delivery. Rguhs J Pharm Sci 2014;1:7-16.

Takagi H, Kajiyama A, Yanagisawa M. Rapidly disintegrable pharmaceutical composition. U. S. Patent; 2005;6:899.

Divate S, Kunchu K, Sockan GN. Fast disintegrating tablets–anemerging trend. Int J Pharm Sci Rev Res 2011;2:18-22.

Mohan SC, Margret CR. Recent advances in orodispersible tablets: a review. Int J Drug Discovery Herbal Res 2011;2:78-83.

Kuchekar BS, Badha AC, Mahajan HS. Mouth dissolving tablets: a novel drug delivery system. Pharmatimes 2003;35:7-9.

Sharma S. New generation of the tablet: fast dissolving tablet. Latest Rev Pharmainfo Net; 2008. p. 6.




About this article

Title

REVIEW: FAST DISSOLVING TABLET

Keywords

Fast Dissolving Drug Delivery System, Superdisintegrants, Advantages of FDT, Patented Technology

DOI

10.22159/ijcpr.2018v10i2.25876

Date

15-03-2018

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 10, Issue 2 (Mar-Apr), 2018 Page: 5-12

Online ISSN

0975-7066

Statistics

91 Views | 27 Downloads

Authors & Affiliations

Aher Smita S.
Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, India

Saudagar R. B.
Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, India

Shinde Mayuri S.
Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, India


Refbacks

  • There are currently no refbacks.