A REVIEW ON: ATRIGEL–THE MAGICAL TOOL


Sali S. R., Gondkar S. B., Saudagar R. B.

Abstract


The widely effective and most common form of drug delivery is parenteral administration for active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. Though parenteral administration of drug is often critical and associated with problems such as limited number of acceptable excipients, stringent requirements of aseptic production process, safety issues, patient noncompliance. Still this route maintains its value due to special advantages like quicker onset of action in case of emergency, target the drug quickly to desired site of action, prevention of first pass metabolism etc. The application of advanced drug delivery technology to parenteral administration lead to development of liposomes, nanosuspensions, solid implants etc. to overcome limitations of conventional parenteral delivery. Solid implants are reported to produce very reproducible release profiles. However, because of their size, they require surgical implantation or the use of large trochars to administer the product. Delivery systems consisting of microparticles can be injected into the body using conventional needles and syringes and have been the most widely accepted biodegradable polymer system for parenteral use. However, the manufacturing processes for microparticles are often complex and difficult to control leading to batch-to-batch product non uniformity. These methods of administration often limit the product's market potential due to patient and physician acceptance issues. Therefore, a delivery system that combines the simplicity and reliability of solid implant devices alongwith convenience and ease of administration of microparticles is desired. In situ gel forming systems represent a desired alternate. This article gives the idea about In situ gel forming system to provide drug release in sustained release manner.


Keywords


Parenteral controlled delivery systems, Atrigel, Biodegradable polymers, Implants, Liposomes, in situ gel forming systems

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About this article

Title

A REVIEW ON: ATRIGEL–THE MAGICAL TOOL

Keywords

Parenteral controlled delivery systems, Atrigel, Biodegradable polymers, Implants, Liposomes, in situ gel forming systems

DOI

10.22159/ijcpr.2018v10i2.25890

Date

15-03-2018

Additional Links

Manuscript Submission

Journal

International Journal of Current Pharmaceutical Research
Vol 10, Issue 2 (Mar-Apr), 2018 Page: 38-42

Online ISSN

0975-7066

Statistics

28 Views | 31 Downloads

Authors & Affiliations

Sali S. R.
Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, India

Gondkar S. B.
Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, India

Saudagar R. B.
Department of Pharmaceutics, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik 422213, Maharashtra, India


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