SCREENING OF PHYTOCHEMICALS AND BIOACTIVE COMPOUNDS IN PUNICA GRANATUM PEEL TO EVALUATE ITS HEMATOLOGICAL POTENTIAL
Pomegranate has been found to have ethnomedical history and is a rich reservoir of phytochemicals. The present study was carried out for phytochemical analysis in the hydroalcoholic pomegranate peel extracts. Presently phytochemical analysis and analysis of bioactive compounds are done, the pomegranate peel extracts are found to have carbohydrates, alkaloids, flavonoids, steroids, tannic acids and phenolic compounds. The antioxidant activity, DPPH free radical scavenging activity, nitric oxide radical scavenging activity was analyzed. For good health the quality of blood should be maintained and for this antioxidants may be the key so as to protect the blood from oxidative stress. Thus from the present study it is concluded that pomegranate peel is a rich source of phytochemicals and bioactive compounds such as antioxidants and so can be used for various pharmaceutical and therapeutic purposes like increase in hemoglobin count.
Keywords: pomegranate peel, antioxidant activity, DPPH free radical scavenging, nitric oxide radical scavenging, hemoglobin booster.
2. Sharma J et.al Pomegranate Phytochemicals: Nutraceutical and Therapeutic Values, Fruit, Vegetable and Cereal Science and Biotechnology. 29th Oct 2010.
3. Mutahar S, Shibanet.al, Antioxidant Activity of Pomegranate (Punica granatumL.) Fruit Peels, Food and Nutrition Sciences. 2012; 3:991-996.
4. Huang DO and Prior BR, The Chemistry behind Antioxidant Capacity Assays.â€ Journal of Agriculture and Food Chemistry. 2005; Vol. 53; No. 6:1841-1856.
5. Balasundram N, Sundram K And Samman S. Phenolic Compounds in Plants and Agri-Industrial By-Products: Antioxidant Activity, Occurrence, and Potential Uses.â€ Food Chemistry. 2006;Vol. 99, No1 :191-203.
6. Reddy M, Gupta S, Jacob M, Khan S and Ferreira D, Antioxidant, Antimalarial and Antimicrobial Activities of Tannin-Rich Fractions, Ellagitannins and Phenolic Acids from Punica granatum L.â€ Planta Medica. 2007; Vol. 73, No. 5: 461-467.
7. Li Y, Guo C, Yang J, Wei J, Xu J and Cheng S, Evaluation of Antioxidant Properties of Pomegranate Peel Extract in Comparison with Pomegranate Pulp Extract.â€ Food Chemistry. Vol. 96, No. 2, 2006. pp. 254-260.
8. Reddy M, Gupta S, Jacob M, Khan S and Ferreira D, Antioxidant, Antimalarial and Antimicrobial Activities of Tannin-Rich Fractions, Ellagitannins and Phenolic Acids from Punica granatum L.â€ Planta Medica. Vol. 73; No. 5, 2007: 461-467.
9. Iqbal S, Haleem S, Akhtar M, Zia-ul-Haq M and Akbar J, Efficiency of Pomegranate Peel Extracts in Sta- bilization of Sunflower Oil under Accelerated Conditions.â€ Food Research International;Vol. 41, No. 2, 2008: pp. 194-200.
10. Negi P and Jayaprakasha J. Antioxidant and Antibacterial Activities of Punica granatum Peel Extracts.â€ Journal of Food Science. Vol. 68, No. 4, 2003:pp. 1473-1477.
11. Murthy KC, Jayaprakasha G and Singh R. Antioxidant Activity of Pomegranate Peel Extracts in Vivo Models.â€ Journal of Agriculture and Food Chemistry. Vol. 50; No. 17, 2002:pp. 4791-4795.
12. Iqbal S, Haleem S, Akhtar M, Zia-ul-Haq M and Akbar J. Efficiency of Pomegranate Peel Extracts in Stabilization of Sunflower Oil under Accelerated Conditions.â€ Food Research International. Vol. 41; No. 2, 2008, pp. 194-200.
13. Surya Prabha M, Santhosh Aruna M, Gulshan MD, Laxshmi Prasanna J, Rama Rao N. Preliminary And Pharmacognostic Investigation On Leaves Of Punica Granatumâ€.Int.Res.J.Pharm.2013:4(12).
14. Olaleye MT. Cytotoxicity and antibacterial activity of methanolic extracts of Hibiscus Sabdariffa.â€ Journal of Medicinal Plants Research. 2007;1:9-13.
15. Brain FH, Thomas Bigger J, Goodman G. The Pharmacological Basis of Therapeutics.â€ MacMillan, New York: NY, USA; 1985.p.7.
16. Ayoola GA, Coker HAB, Adesegun SA, Adepoju Bello AA, Obaweya K, Ezennia EC, Atangbayila TO. Phytochemical screening and antioxidant activities of some selected medicinal plants used for malaria therapy in southwestern Nigeria.â€ Trop J Pharma Res. 2008; 7(3):1019â€1024.
17. Morsi RMY, Tahan NREL, El-Hadad AMA. Effect of aqueous extract Mangifera Indica leaves, as functional foods.â€ J ApplSci Res. 6: 712.
18. Singh RP, Murthy KNC, Jayaprakasha GK (2002) Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models. J Agric Food Chem. 50: 81-86.
19. Yen GC, Chen HY. Comparison of antimutagenic effect of various tea extracts (green, oolong, pouchong and black tea)â€. Journal of Food Protection. 1994; 57: 54-58.
20. Kaliyan Barathikannan et.al. Chemical Analysis of Punica granatum fruit peel and its in vitro and in vivo biological propertiesâ€. BMC Complementary and Alternative Medicine 2016;16:264.
21. Al-Zoreky NS. Antimicrobial activity of pomegranate (Punicagranatum L.) fruit peels. Int J Food Microbiol. 2009; 134(3):244â€“8.
22. Punica granatum peel extracts using different solvent system. Int J Pharmacol Screen Methods. 2014; 4(1):26â€“31.