NUTRIGENOMICS INTERVENTION TOWARD ALTERNATIVE THERAPY OF HYPERCHOLESTEROLEMIA BY DIETARY BIOACTIVES: POLYPHENOLS


Mijanur Rahman, Shahdat Hossain

Abstract


Hypercholesterolemia is a clinical situation characterized by the elevated serum cholesterol and associated with the higher risk of cardiovascular disease, hypertension and stroke. Though current therapeutic strategies of hypercholesterolemia meet the present treatment demand but their efficacy is in question as well as the emergence of medicinal resistance. Demand of new therapeutic strategies is obvious while alternative therapeutic strategies are highly promising. A nutrigenomics intervention is must in that respect but current experimental findings are still ambiguous and scarce.  Several transcription factors playing vital role in cholesterol homeostasis and hypercholesterolemia change their expression profile in response to dietary polyphenols like PPARs, SREBPs, SHP, LXR, FXR etc. Function and expression of a number of proteins considered as therapeutically important regarding hypercholesterolemia like HMG-CoA reductase, CYP7A1, CETP, ABCA1 etc. are modulated by the dietary polyphenols. Experimental paradigm lacks to show the effect of polyphenols in metabolite profile under hypercholesterolemia. Therefore, the Nutrigenomics approach toward the alternative therapy of the hypercholesterolemia by dietary bioactive like polyphenols should be focused and flourished for development of more efficient, highly specific and natural therapeutic approaches.


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About this article

Title

NUTRIGENOMICS INTERVENTION TOWARD ALTERNATIVE THERAPY OF HYPERCHOLESTEROLEMIA BY DIETARY BIOACTIVES: POLYPHENOLS

Date

01-04-2013

Additional Links

Manuscript Submission

Journal

Innovare Journal of Food Sciences
Vol 1 Issue 1 2013 (Apr-Jun) Page: 1-7

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Authors & Affiliations

Mijanur Rahman

Shahdat Hossain
Professor Laboratory of Alternative Medicine & Behavioral Neurosciences Department of Biochemistry and Molecular Biology Faculty of Biological Sciences Jahangirnagar University Savar, Dhaka- 1342
Bangladesh


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