NUTRIGENOMICS INTERVENTION TOWARD ALTERNATIVE THERAPY OF HYPERCHOLESTEROLEMIA BY DIETARY BIOACTIVES: POLYPHENOLS

Abstract

Hypercholesterolemia is a clinical situation characterized by the elevated serum cholesterol and associated with the higher risk of cardiovascular disease, hypertension and stroke. Though current therapeutic strategies of hypercholesterolemia meet the present treatment demand but their efficacy is in question as well as the emergence of medicinal resistance. Demand of new therapeutic strategies is obvious while alternative therapeutic strategies are highly promising. A nutrigenomics intervention is must in that respect but current experimental findings are still ambiguous and scarce.  Several transcription factors playing vital role in cholesterol homeostasis and hypercholesterolemia change their expression profile in response to dietary polyphenols like PPARs, SREBPs, SHP, LXR, FXR etc. Function and expression of a number of proteins considered as therapeutically important regarding hypercholesterolemia like HMG-CoA reductase, CYP7A1, CETP, ABCA1 etc. are modulated by the dietary polyphenols. Experimental paradigm lacks to show the effect of polyphenols in metabolite profile under hypercholesterolemia. Therefore, the Nutrigenomics approach toward the alternative therapy of the hypercholesterolemia by dietary bioactive like polyphenols should be focused and flourished for development of more efficient, highly specific and natural therapeutic approaches.