COMPARATIVE STUDY ON ACTIVITIES OF ANTI BACILLARY DYSENTRY SHIGELLA DYSENTERIAE OF SYZYGIUM POLYANTHUM AND DRACAENA ANGUSTIFOLIA LEAVES ETHANOL EXTRACTS

  • Resmi Mustarichie Faculty of Pharmacy, Univeristas Padjadjaran, Indonesia 45363
  • Sri Agung Fitri
  • Danni Ramdhani

Abstract

Objective: This study aims to determine the antibacterial activity of ethanol extract of bay (Syzygium polyanthum W.) and suji (Dracaena angustifoliaRoxb.) leaves against Shigella dysenteriae and the amount of potassium to the discovery of anti-dysentery drug candidates.

Methods: Testing activities and comparative value activities performed by the agar diffusion method, whereas the determination of minimum bactericidal concentration (MBC) was done with the subculture media incubation test followed with microdilution method on Mueller Hinton Agar medium sterile. Potassium levels of the extract were carried out quantitatively using atomic absorption spectrophotometry.

Results: The test results showed that the ethanol extract of both leaves had antibacterial activity against S. dysenteriae with MBC values were in the range of 10-20% w/v. Value comparative effectiveness suji leaf ethanol extract to the bay leaf was 1:0.4. Potassium levels ethanol extract of bay and suji leaves were 1.027% and 3.795%, respectively.

Conclusion: It can be concluded that the ethanol extract of bay and suji leaves has antibacterial activity against bacteria S. dysenteriae ATCC 13313. Rated comparative activity of the ethanol extract of the suji leaves with bay leaves ethanol extract was 1:0.4 which means to generating resistor diameter equal to 1 part suji leaf ethanol extract equivalent to 0.4 parts of the ethanol extract of bay leaves. The minimum kill concentration ethanol extract of bay and suji leaves ethanol extract was in the range of 10-20% w/v. Both bay and suji leaves have potential as a supplier of potassium in patients with hypokalemia dysentery.

Keywords: Bay leaves, Suji leaves, Shigella dysenteriae, Potassium, Atomic absorption spectrophotometry.

 

Author Biography

Resmi Mustarichie, Faculty of Pharmacy, Univeristas Padjadjaran, Indonesia 45363
Departement of Phamaceutical Analysis and Medicinal Chemistry

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How to Cite
Mustarichie, R., S. A. Fitri, and D. Ramdhani. “COMPARATIVE STUDY ON ACTIVITIES OF ANTI BACILLARY DYSENTRY SHIGELLA DYSENTERIAE OF SYZYGIUM POLYANTHUM AND DRACAENA ANGUSTIFOLIA LEAVES ETHANOL EXTRACTS”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 2, Feb. 2017, pp. 348-52, doi:10.22159/ajpcr.2017.v10i2.15725.
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Original Article(s)