ACUTE TOXICITY EVALUATION OF ETHANOL EXTRACT OF CURCUMA MANGGA RHIZOME

  • Yuandani Universitas Sumatera Utara
  • Edy Suwarso Universitas Sumatera Utara

Abstract

Objective: Curcuma mangga is highly valued in traditional medicines. This study was carry out to evaluate the in vivo acute toxicity of C. mangga.

Methods: Acute toxicity of ethanol extract of C. mangga rhizome was evaluated in mice. The extract at a single dose of 500, 1000, 2000 and 5000 mg/kg body weight (BW) were orally administered to the test animal. Signs of toxicity, BW and mortality were observed for 14 days. The macropathology dan histopathology examination was also performed.

Results: The highest dose administered (5000 mg/kg BW) did not produce mortality of the test animals. Hence, the lethal dose 50 of ethanol extract of C. mangga was estimated to be more than 5000 mg/kg. No sign of toxicity was observed except lethargy. All the organs displayed normal color and texture. Histopathological examination did not show any lesion except for highest dose.

Conclusion: The results indicate the safety of ethanol extract of C. mangga rhizome to the animal tested. Therefore, this plant can be used as a safe and effective alternative medicine.

Keywords: Curcuma mangga, Acute toxicity, Mortality.

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How to Cite
Yuandani, and E. Suwarso. “ACUTE TOXICITY EVALUATION OF ETHANOL EXTRACT OF CURCUMA MANGGA RHIZOME”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 1, Jan. 2017, pp. 383-5, doi:10.22159/ajpcr.2017.v10i1.16196.
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