IMMUNOMODULATORY EFFECTS OF ETHANOL EXTRACT ARTEMISIA VULGARIS L. IN MALE RATS
Keywords:Immunomodulatory, Artemisia vulgaris, Carbon clearance, Leukocyte
Â Objective: This current study was conducted to investigate the immunomodulatory effects of ethanol extract of Artemisia vulgaris in male rats.
Methods: Immunomodulatory activity was determined by measuring the carbon elimination rate, the total number of leukocytes and differential, as well as antibody titer. The treatment groups were divided into six groups, each group consisting of five male rats. The extract at doses of 50, 100, 200, and 400 mg/kg bw was administered orally for 7 days. The carbon elimination was measured using an ultraviolet-visible spectrophotometer.
Results: The ethanol extract of A. vulgaris at doses of 50, 100, 200, and 400 mg/kg body weight increased the carbon elimination and increased the number of total leukocytes and differential leukocytes, especially neutrophils and neutrophils rod segments as compared to the negative control group (CMC-Na 0.5%) (p<0.05).
Conclusion: The ethanol extract of A. vulgaris possesses immunomodulatory effect.
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