RELAXATION EFFECT OF ETHANOLIC EXTRACT OF AVERRHOA BILIMBI L. LEAVES ON ILEUM SMOOTH MUSCLE CONTRACTION OF IN VITRO ISOLATED RAT (RATTUS NORVEGICUS)
Keywords:Averrhoa bilimbi L, Serotonin (5-HT), 5-HT3 receptor, Ethanolic extract
Objective: The study was aimed to investigate the relaxation effect of ethanolic extract of Averrhoa bilimbi L. leaves (EEABL) and ondansetron against 5-HT-induced contraction of the 5-HT3 receptor.
Methods: The study of the relaxation effect of the cumulative concentration EEABL leaves (0.5â€“4 mg/mL) and ondansetron (10âˆ’5â€“3Ã—10âˆ’2) after the contracted with 5-HT (EC80: 1.158Ã—10âˆ’6 M) was conducted in vitro using isolated rat's ileum organ in the Tyrode solution.
Results: The EEABL and ondansetron decreased ileum contraction after induced by 5- HT. EEABL has no difference in terms of ability as ondansetron in reducing the ileum smooth muscle contraction induced by 5-HT (p>0.05).
Conclusion: The EEABL has relaxation effect on smooth muscle of rat's isolated ileum which has induced by 5-HT.
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