INHIBITION OF CARSINOGENESIS BY SEED AND SOYBEAN MEAL EXTRACT IN COLON OF MICE: APOPTOSIS AND DYSPLASIA


Ade Arsianti Arsianti, Anindini Winda Amalia, Kusmardi Suid, Berna Elya

Abstract


Objective: Colon cancer is a major public health problem. Soybean has demonstrated chemopreventive and anticancer. Here, we have investigated
the effect of a standardized seed and soybean meal extract (SE) with content of lunasin, here named grobogan extract (GE) and SE. They are botanical
drug substance in experimental models of colon cancer in vivo.

Methods: The effect of GE and SE was examined on the preneoplastic lesions (aberrant crypt foci), polyps and tumors induced by the carcinogenic
agent azoxymethane (10 mg/kg) and dextran sodium sulfate 2% as well as in a xenograft model of colon cancer in mice.

Results: GE and SE increased apoptosis (p=0.001). GE (150 mg/kg) has the highest impact level of apoptosis (p=0.009). GE and SE decreased dysplasia
(p=0.024). GE (200 mg/kg) has the highest impact level of dysplasia (p=0.002), and SE (200 mg/kg) has the second impact level of dysplasia (p=0.003).

Conclusions: GE and SE inhibition of colon carcinogenesis with increased level of apoptosis and decrease level of dysplasia.

Keywords:Soybean, Lunasin, Colon cancer, Azoxymethane, Dextran sodium sulfate, Apoptosis, Dysplasia.


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About this article

Title

INHIBITION OF CARSINOGENESIS BY SEED AND SOYBEAN MEAL EXTRACT IN COLON OF MICE: APOPTOSIS AND DYSPLASIA

DOI

10.22159/ajpcr.2017.v10i4.16276

Date

01-04-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 4 April 2017 Page: 123-128

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

26 Views | 34 Downloads

Authors & Affiliations

Ade Arsianti Arsianti
Faculty of Medicine, University of Indonesia
Indonesia

Anindini Winda Amalia
Faculty of Pharmacy, University of Indonesia
Indonesia

Kusmardi Suid
Faculty of Medicine University of Indonesia
Indonesia

Berna Elya
Faculty of Pharmacy University of Indonesia

 

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