ANTIOXIDANT ACTIVITY AND INHIBITION OF LIPOXYGENASE ACTIVITY ETHANOL EXTRACT OF ENDOSPERM ARENGA PINNATA (WURMB) MERR.


Berna Elya, Nuraini Puspitasari, Annisa Chairani Sudarmin

Abstract


Objective: The purpose of this study is to determine the antioxidant activity and the potential inhibition of lipoxygenase activity from sugar palm fruit.

Methods: Antioxidant activity was evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) methods. Inhibition of lipoxygenase activity was performed in vitro. Sugar palm fruit was macerated with 95% ethanol.

Results: The results showed that sugar palm fruit ethanol extract has antioxidant activity when using DPPH method with EC50 of 141.3929 μg/mL and the FRAP method with EC50 of 60.2083 μg/mL. Inhibition test of lipoxygenase activity showed inhibitory concentration 50% value of 71.376 μg/mL.

Conclusions: Ethanol extract of endosperm Arenga pinnata has antioxidant activity, as determined using the DPPH method with EC50of 141.3929 μg/mL and the FRAP method with EC50 of 60.2083 μg/mL.


Keywords


Arenga pinnata, Sugar palm fruit, 2,2-Diphenyl-1-picrylhydrazyl, Ferric reducing antioxidant power, Lipoxygenase.

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About this article

Title

ANTIOXIDANT ACTIVITY AND INHIBITION OF LIPOXYGENASE ACTIVITY ETHANOL EXTRACT OF ENDOSPERM ARENGA PINNATA (WURMB) MERR.

Keywords

Arenga pinnata, Sugar palm fruit, 2,2-Diphenyl-1-picrylhydrazyl, Ferric reducing antioxidant power, Lipoxygenase.

DOI

10.22159/ajpcr.2017.v10s5.23102

Date

01-10-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol. 10, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 76-80

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

90 Views | 39 Downloads

Authors & Affiliations

Berna Elya
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Nuraini Puspitasari
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Annisa Chairani Sudarmin
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia


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