PREDOMINANCE AND INFLUENCE OF VITAMIN D DEFICIENCY ON GLYCEMIC AND LIPID INDICES IN TYPE 2 DIABETES SUBJECTS: A CASE CONTROL STUDY

  • Yalla Durga Rao Kasturba Medical College, Mangaluru, Manipal University
  • Manjrekar P A Kasturba Medical College, Mangaluru, Manipal University
  • Prabha Adhikari Yenepoya University, Mangaluru
  • Arun S Kasturba Medical College, Mangaluru, Manipal University
  • Chakrapani M Kasturba Medical College, Mangaluru, Manipal University
  • Rukmini M S Kasturba Medical College, Mangaluru, Manipal University

Abstract

Objective

To investigate the existence of vitamin D deficiency (VDD) among type 2 diabetes, non-diabetes subjects and its effect on both glycemic and lipid profiles.

Methods

A case control study was conducted on 200 subjects of both gender (100 type 2 diabetes and 100 non-diabetes individuals) aged 40 to 60 years. Fasting serum 25(OH) D levels, Fasting Blood Sugar (FBS), HbA1C, lipid profile including total cholesterol, triglycerides, high density lipoprotein, low density lipoprotein TC/HDL and very low density lipoprotein were estimated. Atherogenic Index of Plasma (AIP) was calculated. Group comparisons were done by one way ANOVA followed by post hoc Tukey’s test and Student’s independent T test. Chi-square test was performed for categorical variables. Correlation was done by Pearson’s analysis. P < 0.05 was considered significant.

Results

The average serum 25(OH) D levels were significantly (p<0.001) low in diabetes group. The prevalence of VDD and the percentage of insufficient and sufficient categories was significantly (p<0.001) high and low respectively in diabetes group. In the deficient category diabetes group had severe VDD with significantly low HDL and elevated triglycerides and there was an insignificant but negative association between serum vitamin D levels, FBS, HbA1c, TC, TG, LDL, TC / HDL and AIP among diabetes subjects.

Conclusion

The occurrence of severe vitamin D deficiency coupled with the independent association of the same with the glycemic and lipid profiles in type 2 diabetes may further add to the aggravation of complications 

Keywords: Vitamin D deficiency, Type 2 diabetes, Glycemic and lipid indices

Author Biographies

Yalla Durga Rao, Kasturba Medical College, Mangaluru, Manipal University
Research Scholar, Department of Biochemistry
Manjrekar P A, Kasturba Medical College, Mangaluru, Manipal University
Professor and Head, Department of Biochemistry
Prabha Adhikari, Yenepoya University, Mangaluru
Professor and Head, Department of Internal Medicine
Arun S, Kasturba Medical College, Mangaluru, Manipal University
Associate Professor, Department of Internal Medicine
Chakrapani M, Kasturba Medical College, Mangaluru, Manipal University
Professor, Department of Internal Medicine
Rukmini M S, Kasturba Medical College, Mangaluru, Manipal University
Associate Professor, Department of Biochemistry

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Rao, Y. D., M. P. A, P. Adhikari, A. S, C. M, and R. M. S. “PREDOMINANCE AND INFLUENCE OF VITAMIN D DEFICIENCY ON GLYCEMIC AND LIPID INDICES IN TYPE 2 DIABETES SUBJECTS: A CASE CONTROL STUDY”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 4, Apr. 2017, pp. 177-80, doi:10.22159/ajpcr.2017.v10i4.16437.
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