• Anupama Hegde Associate Professor Department of Biochemistry KMC Mangalore, Manipal University
  • Chakrapani M ProfessorDepartment of Internal MedicineKMC Mangalore,Manipal University
  • SATHISH RAO Additional ProfessorDepartment of Internal MedicineKMC Mangalore, Manipal University
  • Poornima Manjrekar Professor and Head Department of Biochemistry KMC Mangalore,Manipal University
  • Rukmini MS Associate ProfessorDepartment of Biochemistry KMC Mangalore,Manipal University


Objective: Subclinical hypothyroidism (SCH) with thyroid-stimulating hormone (TSH) less than 10 µIU/ml is a common finding discovered during
routine thyroid function testing. Thyroxine substitution and its benefits to alleviate dyslipidemia and oxidative stress (OXs) markers at this stage are
a matter of debate.

Methods: This study aimed to investigate the influence of thyroxine substitution on lipid profile and OXs markers in newly diagnosed SCH subjects.
The study included a total number of 50 newly diagnosed (20 treated and 30 untreated), SCH subjects aged 20-50 years with (TSH<10 µIU/ml), and
free thyroxine (FT4) levels in the normal range. Patients on medications that could cause thyroid hormone dysfunction, diabetes mellitus, and current
or pregnancy during the last 2 years were excluded from the study. Serum TSH, T3, T4, FT4, anti-thyroid peroxidase antibodies, total cholesterol (TC),
high-density lipoprotein cholesterol (HDL), triglycerides (TG), low-density lipoprotein cholesterol (LDL), and ischemia modified albumin (IMA) were
determined in all subjects at baseline and after 9 months.

Results: After thyroxine replacement, a significant decrease in TSH, LDL, IMA and an increase in FT4 were observed. The decrease in TC was not
statistically evident. There was no significant change in T3, T4, TG, HDL, after treatment. The untreated group showed an insignificant increase only
in TSH.

Conclusion: Thyroid substitution therapy has a favorable influence on lipid profile and OXs, where it particularly reduced LDL and IMA.

Keywords: Subclinical hypothyroidism, L-thyroxine, Lipids, Ischemia-modified albumin, Oxidative stress.

Author Biography



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How to Cite
T, J., A. Hegde, C. M, SATHISH RAO, P. Manjrekar, and Rukmini MS. “LIPIDS AND ISCHEMIA MODIFIED ALBUMIN IN MILD SUBCLINICAL HYPOTHYROIDISM: RESPONSE TO LEVOTHYROXINE REPLACEMENT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, no. 5, May 2017, pp. 336-8, doi:10.22159/ajpcr.2017.v10i5.17373.
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