CORRELATION OF THYROID-STIMULATING HORMONE AND PROLACTIN LEVELS IN NON-PREGNANT FEMALE
Objective: The objective of the study was to correlate prolactin (PRL) levels with different levels of thyroid-stimulating hormone (TSH).
Methods: The study included 221 non-pregnant females of the age group of 16–43 years. TSH and PRL were assayed. Subjects were divided into three groups based on TSH levels, namely, low, normal, and high TSH levels and results compared.
Statistical analysis: The comparison between different groups was done using test ANOVA. Correlation between TSH and PRL was established using Pearson’s correlation test.
Results: Five subjects in Group-1 with low TSH values (mean 0.096±0.08 μIU/ml) had PRL 9.8±6.25 ng/dl, 186 subjects in Group-2 with normal TSH values (mean 1.98±0.94 μIU/ml) had PRL 16.58±8.78 ng/dl, and in Group-3 with high TSH values (mean 6.45±3.91 μIU/ml) had PRL 26.53±15.98 ng/dl. p value for TSH is <0.001 (significant) and for PRL also is <0.001 (significant). Positive correlation has been found in overall 221 subjects between TSH and PRL with correlation coefficient r=0.239 and p=0.01 (significant).
Conclusion: PRL levels were higher in group with high TSH values. In most previous studies (subjects with established subclinical or overt hypothyroid), PRL was found higher with higher TSH levels. This study showed strong positive association between TSH and PRL irrespective of the thyroid status.
2. Hekimsoy Z, Kafesçiler S, Güçlü F, Ozmen B. The prevalence of hyperprolactinaemia in overt and subclinical hypothyroidism. Endocr J 2010;57:1011-5.
3. Prabhakar VK, Davis JR. Hyperprolactinaemia. Best Pract Res Clin Obstet Gynaecol 2008;22:341-53.
4. Serri O, Chik CL, Ur E, Ezzat S. Diagnosis and management of hyperprolactinemia. CMAJ 2003;169:575-81.
5. Foord SM, Peters JR, Dieguez C, Jasani B, Hall R, Scanlon MF. Hypothyroid pituitary cells in culture: An analysis of thyrotropin and prolactin responses to dopamine (DA) and DA receptor binding. Endocrinology 1984;115:407-15.
6. Davis JR, Lynam TC, Franklyn JA, Docherty K, Sheppard MC. Tri-iodothyronine and phenytoin reduce prolactin messenger RNA levels in cultured rat pituitary cells. J Endocrinol 1986;109:359-64.
7. Raber W, Gessl A, Nowotny P, Vierhapper H. Hyperprolactinaemia in hypothyroidism: Clinical significance and impact of TSH normalization. Clin Endocrinol (Oxf) 2003;58:185-91.
8. Meier C, Christ-Crain M, Guglielmetti M, Huber P, Staub JJ, Müller B. Prolactin dysregulation in women with subclinical hypothyroidism: Effect of levothyroxine replacement therapy. Thyroid 2003;13:979-85.
9. Shrestha S, Neupane S, Gautam N, Dubey RK, Jha AC, Doshi NR, et al. Association of thyroid profile and prolactin level in patient with secondary amenorrhea. Malays J Med Sci 2016;23:51-6.
10. Sharma LK, Sharma N, Gadpayle AK, Dutta D. Prevalence and predictors of hyperprolactinemia in subclinical hypothyroidism. Eur J Intern Med 2016;35:106-10.
11. Anwary SA, Fatima P, Alfazzaman M, Mahzabin Z, Rahman MM, Bari N. Serum prolactin level of subfertile women. Mymensingh Med J 2016;25:91-5.
12. Kataria J, Gill GK, Kaur M. Interrelationship of thyroid hormones, obesity, and prolactin in infertile women. Asian J Pharm Clin Res 2018;11:136-7.
13. Hakeim HK, Jebur IM, Rahim AI. Sirt6 is correlated with estradiol in women with in vitro fertilization failure. Int J Pharm Pharm Sci 2016;8:184-8.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.