BACTERIOLOGICAL PROFILE AND ANTIBIOTIC SENSITIVITY PATTERN OF HOSPITALACQUIRED SEPTICEMIA IN A TERTIARY CARE HOSPITAL IN NORTH EAST INDIA


Aroop Mohanty, Shantikumar Singh T, Ankita Kabi, Pratima Gupta, Priyanka Gupta, Pradeep Kumar

Abstract


Objective: The objective of this study was to determine the bacterial agents responsible for hospital acquired septicaemia and to determine the antibiotic sensitivity profile of the bacterial isolates.

Methods:  Three hundred fifty hospitalized clinically suspect septicaemia cases were included in this cross sectional observational study during a period of one year. Blood samples were collected with aseptic precautions for culture following universal precautions. Anti-microbial susceptibility test of the bacterial isolates was performed according to Clinical and Laboratory Standards Institute (CLSI, USA) guidelines.    

Results: Over two-thirds of cultures showed gram positive organism. The most frequently identified Gram positive bacteria were coagulase negative staphylococci and Staphylococcus aureus. Among gram negative bacteria Escherichia coli, Klebsiella spp and Salmonella typhi were isolated. In our study, coagulase negative staphylococci showed maximum resistance to penicillin and erythromycin. Enterobactereciae had maximum sensitivity to carbapenems, tigecycline and aminoglycosides.

Conclusion: Gram positive pathogens predominated in the blood stream infections. Résistance to fluoroquinolones, especially in Gram negative bacteria was significantly high. Therefore, rapid microbiological diagnosis and the determinants of antimicrobial susceptibility become relevant for early initiation of antimicrobial therapy.     


Keywords


Coagulase negative staphylococci, Hospital acquired septicemia, Antimicrobial resistance.

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About this article

Title

BACTERIOLOGICAL PROFILE AND ANTIBIOTIC SENSITIVITY PATTERN OF HOSPITALACQUIRED SEPTICEMIA IN A TERTIARY CARE HOSPITAL IN NORTH EAST INDIA

Topics

Clinical Microbiology

Keywords

Coagulase negative staphylococci, Hospital acquired septicemia, Antimicrobial resistance.

DOI

10.22159/ajpcr.2017.v10i11.20554

Date

01-11-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 11 November 2017 Page: 186-189

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

18 Views | 45 Downloads

Authors & Affiliations

Aroop Mohanty
Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
India

Shantikumar Singh T
Department of Microbiology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India.
India

Ankita Kabi
Department of Anesthesia, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
India

Pratima Gupta
Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
India

Priyanka Gupta
Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
India

Pradeep Kumar
Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
India


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