THE MAJOR HISTOCOMPATIBILITY COMPLEX: A REVIEW
One of the important components of the immune system, the major histocompatibility complex (MHC) molecules allow T-lymphocytes to detect cells, such as macrophages, B-lymphocytes, and dendritic cells that ingest infectious microorganisms or the self-cells infected with microorganism. On being engulfed a microorganism, macrophage partially digests it and displays peptide fragments of the microbe on its surface, bound to MHC molecules and the T-lymphocyte recognizes the foreign fragment attached to the MHC molecule and binds to it, lead to stimulation of an immune response. The MHC molecule presents peptides from its own cell (self-peptides) in healthy self-cells to which T-cells do not normally react.
Keywords: MHC, B Cells, T Cells, Antigen Processing.
2. MHC Sequencing Consortium (1999). "Complete sequence and gene map of a human major histocompatibility complex".Nature. 401 (6756): 921â€“923. doi:10.1038/44853.
3. Abbas; Lichtman A.H. (2009). "Ch.3 Antigen capture and presentation to lymphocytes". Basic Immunology. Functions and disorders of the immune system (3rd ed.). p. A.B. ISBN 978-1-4160-4688-2.
4. Abbas; Lichtman A.H. (2009). "Ch.3 Antigen capture and presentation to lymphocytes". Basic Immunology. Functions and disorders of the immune system (3rd ed.). p. A.B. ISBN 978-1-4160-4688-2.
5. Thomas J. Kindt; Richard A. Goldsby; Barbara Anne Osborne; Janis Kuby (2007). Kuby immunology. Macmillan. ISBN 978-1-4292-0211-4. Retrieved 28 November2010.
6. Batista, Facundo D.; Harwood, Naomi E. (January 2009). "The who, how and where of antigen presentation to B cells". Nature Reviews Immunology. Macmillan Publishers Limited. 9: 15â€“27. doi:10.1038/nri2454
7. Fogdell-Hahn A, Ligers A, Gronning M, Hillert J, Olerup O. Multiple sclerosis: a modifying influence of HLA class I genes in an HLA class II associated autoimmune disease. Tissue Antigens. 2000; 55:140â€“148.
8. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, et al. (2003) The DNA sequence and analysis of human chromosome 6. Nature 425: 805â€“811.
9. K. Murphy, â€œAntigen recognition by T cells,â€ in Janeway's Immunobiology, 8th, Ed., Garland Science, 2012, pp. 138-153.
A. Chandraker and J. J. Lacomini, â€œTransplantation immunobiology,â€ in Brenner & Rector's the kidney, B. M. Brenner and S. A. Leivne, Eds., pp. 2104â€“2111, Elsevier Saunders, Philadelphia, Pa, USA, 8th edition, 2007.
11. Elston RC. Probability and paternity testing. Am J Hum Genet. 1986 Jul;39 (1):112â€“122.
12. "Table 2.3: Human chromosome groups". Human Molecular Genetics (2nd ed.). Garland Science. 1999.
13. Kambayashi, Taku; Laufer, Terri M. "Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?". Nature Reviews Immunology. 14 (11): 719â€“730.
14. Gruen JR, Weissman SM: Evolving views of the major histocompatibility complex. Blood. 1997, 90 (11): 4252-4265.
15. Albring J, Koopmann JO, HÃ¤mmerling GJ, Momburg F; Koopmann; HÃ¤mmerling; Momburg (January 2004)."Retrotranslocation of MHC class I heavy chain from the endoplasmic reticulum to the cytosol is dependent on ATP supply to the ER lumen". Mol. Immunol. 40 (10): 733â€“41.
16. Hewitt, E.W. (2003). "The MHC class I antigen presentation pathway: strategies for viral immune evasion". Immunology. 110 (2): 163â€“169.
17. Koopmann JO, Albring J, HÃ¼ter E, et al. (July 2000)."Export of antigenic peptides from the endoplasmic reticulum intersects with retrograde protein translocation through the Sec61p channel". Immunity. 13 (1): 117â€“27.
19. Babbitt BP, Allen PM, Matsueda G, Haber E, Unanue ER. Binding of immunogenic peptides to Ia histocompatibility molecules. Nature. 317 (6035):359â€“361.
20. Castellino F. Antigen presentation by MHC class LL molecules: Invarient chain function, protein trafficking, and the molecular basis of diverse determinant capture. Hum Immunol. 54(2), 159-169, 1997
21. Jason K. Whitmire, Boreth Eam, and J. Lindsay Whitton*Richard A. Koup Tentative T Cells: Memory Cells Are Quick to Respond, but Slow to Divide 2008 Apr; 4(4): e1000041.
22. Savina A, Amigorena S.Phagocytosis and antigen presentation in dendritic cells. Immunol Rev. 2007 Oct; 219:143-56.
23. Akiko Iwasaki and Padmini S. Pillai Innate immunity to influenza virus infectionNat Rev Immunol. 2014 May; 14(5): 315â€“328.
26. Peptide analogs with different affinities for MHC alter the cytokine profile of T helper cells. Int. Immunol. 8:745
27. Hadrup, Sine R.; Bakker, Arnold H.; et al. (2009). "Parallel Detection of Antigen-Specific T-Cell responses by multidimensional encoding of MHC multimers". Nature Methods. 6: 520â€“526.
28. Bakker, Arnold; Schumacher, Tom. "MHC Multimer Technology: Current Status and Future Prospects," Current Opinion in Immunology, Vol. 17, No. 4 (August 2005), pp. 428-433.
29. Lebowitz, M. S (1999). "Soluble, high-affinity dimers of T-cell receptors and class II major histocompatibility complexes: biochemical probes for analysis and modulation of immune responses". Cell. Immunol. 192: 175â€“184
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.