A CORRELATION BETWEEN THYROID STIMULATING HORMONE AND BODY MASS INDEX IN WOMEN WITH SUBCLINICAL HYPOTHYROIDISM IN NCR
Objective: Weight gain is a characteristic feature of hypothyroidism. People with subclinical hypothyroidism (SCH) are also characterized by the same
is still unclear.
Methods: Height and weight were calculated of SCH women as well as normal healthy adult women. Body mass index (BMI) was calculated as per
WHO guidelines. The thyroid stimulating hormone (TSH), FT4, and T3 were measured by Enzyme-Linked Immunosorbent Assay technique.
Results: Thyroid profile (TSH and T3) was significantly (<0.05) different between subclinical hypothyroidism women and normal women. Women
with subclinical hypothyroidism were having higher TSH (13.01Â±4.41 vs. 2.61Â±0.79) compared with normal healthy control group along with different
T3 (0.94Â±0.17Â±1.09Â±0.26) between the groups. The serum concentration of FT4 was not significant between the groups. The body mass index, higher
(28.81Â±3.47 vs. 22.62Â±1.57) in subclinical hypothyroidism women, was highly significant (<0.001). BMI was positively correlated with TSH in SCH
(0.36) group as well as normal control (0.50) group. The correlation was significant (<0.05) in both the groups.
Conclusion: People with subclinical hypothyroidism were characterized by increased weight gain. Thereby it is concluded that Thyroid Stimulating
Hormone affects the Body Mass Index in SCH women. Our result suggests that estimation of thyroid profile, also within the normal range, could be one
of several factors acting in concert to determine body weight. However, this parallel increase in BMI due to weight gain along with increase in TSH may
further leads to overt hypothyroidism if left untreated. Obesity itself could produce various metabolic disorders in coming future.
Keywords: Subclinical hypothyroidism, Body mass index, Thyroid stimulating hormone.
1. Fatourechi V. Subclinical hypothyroidism: An update for primary care
physicians. Mayo Clin Proc 2009;84(1):65-71.
2. Deshmukh V, Behl A, Iyer V, Joshi H, Dholye JP, Varthakavi PK.
Prevalence, clinical and biochemical profile of subclinical
hypothyroidism in normal population in Mumbai. Indian J Endocrinol
3. Fatourechi V. Subclinical hypothyroidism: How should it be managed?
Treat Endocrinol 2002;1(4):211-6.
4. Burtis CA, Ashwood ER, Bruns DE. Teitz Fundamentals of Clinical
Chemistry. 6th ed. St. Louis: Saunders Elsevier; 2008. p. 422-4.
5. Jamson JL. Disorder of thyroid gland. Harrisonâ€™s endocrinology. 2nd ed.,
Vol. 4. New York, NY: McGraw-Hill; 2006. p. 72.
6. Tolonen H. Recommendation for Indicators, International Collaboration,
Protocol and Manual of Operations for Chronic Disease Risk Factor
Surveys. European Health Risk Monitoring. 2002.
7. World Health Organization. Available from: http://www.who.int/
mediacentre/factsheets/fs311/en/index.html. [Last accessed on
8. Milionis A, Milionis C. Correlation between body mass index and thyroid function in euthyroid individuals in Greece. ISRN Biomark
9. Zhang J, Jiang R, Li L, Li P, Li X, Wang Z, et al. Serum thyrotropin
is positively correlated with the metabolic syndrome components
of obesity and dyslipidemia in chinese adolescents. Int J Endocrinol
10. Velivala AP, Paladugu L, Koyyala VP. Subclinical hypothyroidism
in obese patients in rural general hospital. IOSR J Dent Med Sci
11. Karthick N, Dillara K, Poornima KN, Subhasini AS. Dyslipidaemic
changes in women with subclinical hypothyroidism. J Clin Diagn Res
12. Solanki A, Bansal S, Jindal S, Saxena V, Shukla US. Relationship of
serum thyroid stimulating hormone with body mass index in healthy
adults. Indian J Endocrinol Metab 2013;17 Suppl 1:S167-9.
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