ROLE OF MAGNESIUM IN POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS AND OSTEOPENIA
Objective: Osteoporosis is quite common in elderly people, especially in post-menopausal women. The role of Magnesium, an important cation along
with calcium for bone formation, is not very well-studied in osteoporosis as well as osteopenia group.
Methods: Total 68 post-menopausal women 48-75 years of age group, were included in this study. In which, 33 women were having osteoporosis
while rest 35 were from osteopenia. The differentiation between osteoporosis and osteopenia were done with the bone mineral density usually
expressed in T score and Z score. Serum total calcium, ionized calcium, serum phosphate, serum alkaline phosphatase, and serum magnesium were
estimated in post-menopausal women.
Results: Significant results were obtained in various parameters. In osteopenic women, the mean values of total calcium (8.25Â±1.25 vs. 9.29Â±0.62)
and ionized calcium (4.22Â±0.51 vs. 4.64Â±0.31) were significantly (<0.001) higher. The serum concentration of alkaline phosphatase (159.87Â±37.11 vs.
137.21Â±33.29) was significantly higher (<0.01) in osteoporosis group. The serum concentration of magnesium (1.95Â±0.44 vs. 2.22Â±0.42) was lower
in osteoporosis group, and the result was statistically significant (<0.05).
Conclusion: In post-menopausal women, osteoporosis is characterized by a lower concentration of magnesium. Hypomagnesemia may result in
inflammatory disorders which have an existing relationship with bone loss. The dietary intake of magnesium supplement may be useful in reducing
the adverse effect of osteoporosis.
Keywords: Osteoporosis, Post-menopause, Osteopenia, Hypomagnesemia.
1. Riggs BL, Melton LJ 3
. Involutional osteoporosis. N Engl J Med
2. Guggenbuhl P. Osteoporosis in males and females: Is there really a
difference? Joint Bone Spine 2009;76(6):595-601.
3. Faienza MF, Ventura A, Marzano F, Cavallo L. Postmenopausal
osteoporosis: The role of immune system cells. Clin Dev Immunol
4. Varney LF, Parker RA, Vincelette A, Greenspan SL. Classification of
osteoporosis and osteopenia in postmenopausal women is dependent on
site-specific analysis. J Clin Densitom 1999;2(3):275-83.
5. Giannoudis P, Tzioupis C, Almalki T, Buckley R. Fracture healing in
osteoporotic fractures: Is it really different? A basic science perspective.
Injury 2007;38 Suppl 1:S90-9.
6. Nordin BE, Need AG, Morris HA, Oâ€™Loughlin PD, Horowitz M. Effect
of age on calcium absorption in postmenopausal women. Am J Clin
7. Nieves JW. Skeletal effects of nutrients and nutraceuticals, beyond
calcium and vitamin D. Osteoporos Int 2013;24(3):771-86.
8. Mazur A, Maier JA, Rock E, Gueux E, Nowacki W, Rayssiguier Y.
Magnesium and the inflammatory response: Potential physiopathological
implications. Arch Biochem Biophys 2007;458(1):48-56.
9. Baker-LePain JC, Nakamura MC, Lane NE. Effects of inflammation on
bone: An update. Curr Opin Rheumatol 2011;23(4):389-95.
10. Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin Kidney J
2012;5 Suppl 1:i3-14.
11. Rude RK, Kirchen ME, Gruber HE, Meyer MH, Luck JS, Crawford DL.
Magnesium deficiency-induced osteoporosis in the rat: Uncoupling of
bone formation and bone resorption. Magnes Res 1999;12(4):257-67.
12. Sissi C, Palumbo M. Effects of magnesium and related divalent metal
ions in topoisomerase structure and function. Nucleic Acids Res
13. National Osteoporosis Foundation. Available from: http://www.nof.org/
articles/743. [Last accessed on 2015 Sep 30].
14. Burtis CA, Ashwood ER, Burns DE. Tietz Fundamentals of Clinical
ed. Philadelphia: WB Saunders; 1976. p. 715-21.
15. Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP.
Potassium, magnesium, and fruit and vegetable intakes are associated
with greater bone mineral density in elderly men and women. Am J Clin
16. Hejazi J, Mohtadinia J, Kolahi S, Ebrahimi-Mamaghani M. Nutritional
status among postmenopausal osteoporotic women in North West of
Iran. Asia Pac J Clin Nutr 2009;18(1):48-53.
17. Zheng J, Mao X, Ling J, He Q, Quan J, Jiang H. Association between
serum level of magnesium and postmenopausal osteoporosis: A metaanalysis.
Elem Res 2014;159(1-3):8-14.
18. Mutlu M, Argun M, Kilic E, Saraymen R, Yazar S. Magnesium, zinc and
copper status in osteoporotic, osteopenic and normal post-menopausal
women. J Int Med Res 2007;35(5):692-5.
19. Saito N, Tabata N, Saito S, Andou Y, Onaga Y, Iwamitsu A, et al. Bone
mineral density, serum albumin and serum magnesium. J Am Coll Nutr
20. Odabasi E, Turan M, Aydin A, Akay C, Kutlu M. Magnesium, zinc,
copper, manganese, and selenium levels in postmenopausal women
with osteoporosis. Can magnesium play a key role in osteoporosis? Ann
Acad Med Singapore 2008;37(7):564-7.
21. Wang S, Lin S, Zhou Y. Changes of total content of serum magnesium
in elderly Chinese women with osteoporosis. Biol Trace Elem Res
22. Suwansaksri J, Vattanawaha A, Wiwanitkit V. Serum magnesium level
in diabetic and osteoporosis-risk thai female subjects. Internet J Lab
23. Okyay E, Ertugrul C, Acar B, Sisman AR, Onvural B, Ozaksoy D.
Comparative evaluation of serum levels of main minerals and
postmenopausal osteoporosis. Maturitas 2013;76(4):320-5.
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