• Rachna Sharma
  • Preeti Sharma
  • Pradeep Kumar Santosh University
  • Gaurav Gupta


Objective: Osteoporosis is quite common in elderly people, especially in post-menopausal women. The role of Magnesium, an important cation along
with calcium for bone formation, is not very well-studied in osteoporosis as well as osteopenia group.
Methods: Total 68 post-menopausal women 48-75 years of age group, were included in this study. In which, 33 women were having osteoporosis
while rest 35 were from osteopenia. The differentiation between osteoporosis and osteopenia were done with the bone mineral density usually
expressed in T score and Z score. Serum total calcium, ionized calcium, serum phosphate, serum alkaline phosphatase, and serum magnesium were
estimated in post-menopausal women.
Results: Significant results were obtained in various parameters. In osteopenic women, the mean values of total calcium (8.25±1.25 vs. 9.29±0.62)
and ionized calcium (4.22±0.51 vs. 4.64±0.31) were significantly (<0.001) higher. The serum concentration of alkaline phosphatase (159.87±37.11 vs.
137.21±33.29) was significantly higher (<0.01) in osteoporosis group. The serum concentration of magnesium (1.95±0.44 vs. 2.22±0.42) was lower
in osteoporosis group, and the result was statistically significant (<0.05).
Conclusion: In post-menopausal women, osteoporosis is characterized by a lower concentration of magnesium. Hypomagnesemia may result in
inflammatory disorders which have an existing relationship with bone loss. The dietary intake of magnesium supplement may be useful in reducing
the adverse effect of osteoporosis.
Keywords: Osteoporosis, Post-menopause, Osteopenia, Hypomagnesemia.

Author Biography

Pradeep Kumar, Santosh University
Professor of Biochemistry


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How to Cite
Sharma, R., P. Sharma, P. Kumar, and G. Gupta. “ROLE OF MAGNESIUM IN POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS AND OSTEOPENIA”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 198-9,
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