STOOL FORM SCALE AS AN INDICATOR OF KLUTUK BANANA (MUSA BALBISIANA COLLA) FRUIT EXTRACTS INHIBITION EFFECT AGAINST SHIGELLA DYSENTERIAE ATCC 13313 IN VIVO


Sri Agung Fitri Kusuma, Puspagita Wardhani, Ellin Febrina

Abstract


 

 Objective: Stools consistency is a common symptom indicating in dysenteriae. The aim of this study was to investigate the inhibitory effect of the klutuk banana fruit extract that determine different degrees of stool consistency in dysentery induced by Shigella dysenteriae ATCC 13313.

Methods: The extraction of klutuk banana fruits was prepared using a maceration method. The antidysenteriae activity of the klutuk banana extract was evaluated in vivo. The specific pathogen-free mice were intraperitoneally injected with S. dysentriae suspension cell. Observations were made for 7 days on body weight of mice, total fecal weight every 24 hrs and consistency of stool. The level of stool consistency was measured based on Bristol Stool Chart.

Results: The results indicated that the body weight of each group was decreased the day after induction and the stool consistency was at level 5-6. However, both test groups could achieve the ideal type of stool (type 4) in the same period of time as a group with ciprofloxacin treatment.

Conclusion: It can be concluded that the ethanol extract of klutuk banana fruits is highly potent as natural antidysenteriae against S. dysenteriae.


Keywords


Klutuk, Banana, Shigella dysenteriae, Stool, Consistency.

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About this article

Title

STOOL FORM SCALE AS AN INDICATOR OF KLUTUK BANANA (MUSA BALBISIANA COLLA) FRUIT EXTRACTS INHIBITION EFFECT AGAINST SHIGELLA DYSENTERIAE ATCC 13313 IN VIVO

Keywords

Klutuk, Banana, Shigella dysenteriae, Stool, Consistency.

DOI

10.22159/ajpcr.2017.v10i12.21592

Date

01-12-2017

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 10 Issue 12 December 2017 Page: 266-268

Print ISSN

0974-2441

Online ISSN

2455-3891

Statistics

13 Views | 34 Downloads

Authors & Affiliations

Sri Agung Fitri Kusuma
Department of Biology Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java, 45363, Indonesia
Indonesia

Puspagita Wardhani
Department of Biology Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java, 45363, Indonesia
Indonesia

Ellin Febrina
Department of Pharmacology, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java, 45363, Indonesia.
Indonesia


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