INFLUENCE OF DOSAGE ON RETENTION IN PATIENTS METHADONE MAINTENANCE THERAPY PROGRAM FOR MAINTENANCE PHASE OF H. ADAM MALIK MEDAN CENTRAL GENERAL HOSPITAL

  • Robiatun Rambe Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.in
  • Urip Harahap Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
  • Citra Julita Tarigan Department of Pharmacology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

Abstract

 

 Objective: This study aims to see the effect of methadone dose on patient retention in following the program.

Materials and Methods: This study is a clinical study with cross-sectional study design. Data obtained from the patient's medical record and patient's primary data. The study was conducted at Methadone Clinic of H.Adam Malik Hospital Medan.

Results: The number of research samples is injecting drug users who follow PTRM as many as 39 people. From a study of 39 patients, the percentage of male patients (100%) was obtained; age between 25 and 35 years (64.1%); junior high school education equal to 84.6%; already married 46.2%; already working 69.2%; and the distance of the average residence with the clinic is 16.93 km. The results showed that the smallest maintenance dose of maintenance phase was 2 mg; the largest maintenance dose in the maintenance phase was 165 mg; the mean maintenance stage dose of 62.35 mg with a retention value >2 years or more (>730 days) was 79.5%.

Conclusion: There was a significant effect on retention which is the biggest maintenance dose with p=0.04 value and take home dose with p=0.027. Percentage of drug use and other substances that is benzodiazepines (BZO) (64,1%); amphetamines (AMP) (38.5%); methamphetamine (MET) (20.5%); and THC (20.5%). There was no significant effect between the use of other substance to retention with p value of BZO (0.389); p AMP (0.360); p MET (0.195); and p THC (0.470). It can be concluded that the greater the dose of methadone has an effect on its retention.

Keywords: Methadone, Methadone maintenance therapy, Retention.

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Rambe, R., U. Harahap, and C. Julita Tarigan. “INFLUENCE OF DOSAGE ON RETENTION IN PATIENTS METHADONE MAINTENANCE THERAPY PROGRAM FOR MAINTENANCE PHASE OF H. ADAM MALIK MEDAN CENTRAL GENERAL HOSPITAL”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 8, Aug. 2018, pp. 244-7, doi:10.22159/ajpcr.2018.v11i8.24743.
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