IN VITRO ANTINEPHROLITHIASIS EFFECT OF BREADFRUIT (ARTOCARPUS ALTILIS (PARK) FOSBERG) LEAVES EXTRACT BY ATOMIC ABSORPTION SPECTROPHOTOMETRY

Authors

  • Effendy De Lux Putra Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia,
  • Nahitma Ginting Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia,
  • Nazliniwaty Nazliniwaty Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia,
  • Iksen Iksen Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia,
  • Erik Kurniawan Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia,
  • Nerdy Nerdy Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia,

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26607

Keywords:

In vitro, Antinephrolithiasis, Artocarpus altilis, Atomic absorption spectrophotometry

Abstract

 Objective: The objective of this study is to observe the solubility calcium oxalate as a prototype of kidney stone in breadfruit leaf extract solution (n-hexane extract solution, ethyl acetate extract solution, and ethanol extract solution) by atomic absorption spectrophotometry.

Methods: Research was conducted qualitatively to analyze calcium oxalate solubility in breadfruit leaf extract solution. The solubility of calcium was known by measuring the levels of calcium in extract solution before and after incubation with calcium oxalate. Potassium as a factor that can enhance the solubility of calcium oxalate also measured by atomic absorption spectrophotometry.

Results: The higher concentration of extract solution used in incubation with calciumoxalate, the higher dissolving activity of calcium oxalate. The highest activity was found in ethyl acetate extract to dissolve calcium oxalate. Potassium has a small effect on the activity of dissolving calcium oxalate. Activity may be due to the phytochemical content present in the ethyl acetate extract.

Conclusion: Ethyl acetate extract solution has the highest activity to dissolve calcium compared to n-hexane extract and ethanol extract solution.

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Published

2018-04-26

How to Cite

Lux Putra, E. D., N. Ginting, N. Nazliniwaty, I. Iksen, E. Kurniawan, and N. Nerdy. “IN VITRO ANTINEPHROLITHIASIS EFFECT OF BREADFRUIT (ARTOCARPUS ALTILIS (PARK) FOSBERG) LEAVES EXTRACT BY ATOMIC ABSORPTION SPECTROPHOTOMETRY”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 13, Apr. 2018, pp. 206-9, doi:10.22159/ajpcr.2018.v11s1.26607.

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