CYTOTOXICITY ACTIVITY OF PICRIA FEL-TERRAE LOUR. HERBS AGAINST 4T1 AND MCF-7 BREAST CANCER CELLS
Keywords:Cytotoxicity, Picria fel-terrae Lour, Herbs, Fractions, Cell lines
Â Objective: This study was carried out to investigate the cytotoxic activity toward 4T1 and MCF-7 cell lines of Picria fel-terrae Lour. herb fractions.
Methods: P. fel-terrae Lour. herb powder was extracted by maceration method with n-hexane, ethyl acetate, and ethanol solvent. In vitro study was using MTT method toward 4T1 and MCF-7 cell lines.
Results: The inhibitory concentration 50% was 234.10 Â± 7.85, 50.49 Â± 1.07, and 212.53 Â± 7.55 Î¼g/mL for 4T1 and 84.62 Â± 1.44, 56.79 Â± 0.22, and 235.51 Â± 4.77 Î¼g/mL for MCF-7 cell lines, respectively.
Conclusion: The results reveal that P. fel-terrae Lour. herb fractions provide effective as anticancer. Our further study is to assess the mechanism of ethyl acetate fraction in inhibit angiogenesis and metastatic in breast cancer.
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