ANTIDIABETIC EFFECTS OF PUMPKIN (CUCURBITA MOSCHATA DURCH) FLESH AND SEEDS EXTRACTS IN STREPTOZOTOCIN INDUCED MICE

  • Novarianti Marbun Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
  • Panal Sitorus Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
  • Siti Morin Sinaga Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.

Abstract

 Objective: The present study is to investigate the antidiabetic effect of pumpkin flesh and seeds ethanolic extracts in STZ-induced diabetic mice.

Methods: The study begins with making the ethanolic extracts of pumpkin flesh and seeds and then evaluates the physicochemical characterization, phytochemical screening, and induced diabetic mice using STZ.

Result: The physicochemical evaluation shows that the extracts had a good and high purity level, while the phytochemical screening showed both pumpkin flesh and seeds extracts have a various of phytoconstituents. The pumpkin flesh and seeds ethanolic extracts (dose level 150 mg/kg) showed a significant reduction of the blood glucose.

Conclusion: Pumpkin flesh and seeds ethanolic extracts exhibited significant antidiabetes activity in STZ-induced mice.

Keywords: Antidiabetic, Diabetes mellitus, Pumpkin, Streptozotocin, Mice.

Author Biographies

Novarianti Marbun, Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
Department of Biological Pharmacy
Panal Sitorus, Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
Department of Biological Pharmacy
Siti Morin Sinaga, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
Department of Pharmaceutical Chemistry

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Marbun, N., P. Sitorus, and S. M. Sinaga. “ANTIDIABETIC EFFECTS OF PUMPKIN (CUCURBITA MOSCHATA DURCH) FLESH AND SEEDS EXTRACTS IN STREPTOZOTOCIN INDUCED MICE”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 11, no. 2, Feb. 2018, pp. 91-93, doi:10.22159/ajpcr.2018.v11i2.22023.
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