ANTIDIABETIC EFFECTS OF PUMPKIN (CUCURBITA MOSCHATA DURCH) FLESH AND SEEDS EXTRACTS IN STREPTOZOTOCIN INDUCED MICE


Novarianti Marbun, Panal Sitorus, Siti Morin Sinaga

Abstract


 Objective: The present study is to investigate the antidiabetic effect of pumpkin flesh and seeds ethanolic extracts in STZ-induced diabetic mice.

Methods: The study begins with making the ethanolic extracts of pumpkin flesh and seeds and then evaluates the physicochemical characterization, phytochemical screening, and induced diabetic mice using STZ.

Result: The physicochemical evaluation shows that the extracts had a good and high purity level, while the phytochemical screening showed both pumpkin flesh and seeds extracts have a various of phytoconstituents. The pumpkin flesh and seeds ethanolic extracts (dose level 150 mg/kg) showed a significant reduction of the blood glucose.

Conclusion: Pumpkin flesh and seeds ethanolic extracts exhibited significant antidiabetes activity in STZ-induced mice.


Keywords


Antidiabetic, Diabetes mellitus, Pumpkin, Streptozotocin, Mice.

| PDF |

References


Marbun N. Comparison of Blood Glucose Levels Decrease Effectiveness of Pumpkin Flesh and Seeds Toward Diabetic Mice, Thesis, Faculty of Pharmacy, University of Sumatera Utara; 2017. p. 1-106.

Zhang Y, Wu L, Ma Z, Cheng J, Liu J. Anti-diabetic, anti-oxidant and anti-hyperlipidemic activities of flavonoids from corn silk on STZ-induced diabetic mice. Molecules 2015;21:E7.

Parthasarathy R, Illavarasan R, Karrunakaran CM. Antidabetic activity of Thespesia populnea bark and leaf extrct against streptozotocin induced diabetic rats. Int J Pharmtech Res 2009;1:1069-72.

King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: Prevalence, numerical estimates, and projections. Diabetes Care 1998;21:1414-31.

WHO. Definition and Diagnosis of Diabetes Mellitus and Intermediate Hyperglycemia. Geneva: WHO; 2006. p. 1-50.

Rumanti RM. Characterization of Simplicia and Chromatographic Analysis of Active Extract Lotus (Nelumbo nucifera Gaertn) which can Reduce Blood Glucose in Mice, Thesis, Faculty of Pharmacy, University of Sumatera Utara; 2017. p. 1-104.

Lal VK, Gupta PP, Awanish P. Hypoglycemic effect of Kyllinga trceps in STZ induced diabetic rats. J Diabetes Metab 2012;3:1-3.

McCarty MF. Nutraceutical resources for diabetes prevention-an update. Med Hypotheses 2005;64:151-8.

Teugwa CM, Boudjeko T, Tchinda BT, Mejiato PC, Zofou D. Anti-hyperglycaemic globulins from selected Cucurbitaceae seeds used as antidiabetic medicinal plants in Africa. BMC Complement Altern Med 2013;13:63.

Sani UM. Phytochemical screening and antidiabetic effect of extracts of the seeds of Citrullus lanatus in alloxan-induced diabetic albino mice. J Appl Pharm Sci 2015;5:51-4.

Taylor MJ, Brant J. Trends in World Cucurbit Production, 1991-2001.

Alexandria: ASHS Press; 2002. p. 373-9.

Zhao YM, Li XZ, Zhou JG. Worldwide production and diversity characteristics of Cucurbita species. J Inn Mongolia Agric Univ 2004;15:238-41.

Ting Z, Qian K, Jingrong H, Ruitong D, Quanhong L. Characterization of nutritional components and utilization of pumpkin. Food 2007;1:313-21.

Elella FA, Mourad R. Anticancer and anti-oxidant potentials of ethanolic extracts of Phoenix dactylifera, Musa acuminata, and Cucurbita maxima. Res J Pharm Biol Chem Sci 2015;6:710-20.

Sharma A, Sharma AK, Chand T, Khardiya M, Yadav KC. Antidiabetic and antihyperlipidemic activity of Cucurbita maxima (Pumpkin) seeds on streptozotocin induced diabetic rats. J Pharmacogn Phytochem 2013;1:108-16.

Muruganantham N, Solomon S, Senthamilselvi MM. Antimicrobial activity of Cucurbita maxima flowers (Pumpkin). J Pharmacogn Phytochem 2016;5:15-8.

World Health Organization, WHO. Quality Control Methods for Medicinal Plant Materials, WHO/PHARM/92.559. Geneva: WHO; 1998. p. 4-46.

Depkes RI. Materia Medika. Vol. 6. Jakarta: Ditjen POM; 1995. p. 297-307.

Farnsworth NR. Biological and phytochemical screening of plants. J Pharm Sci 1966;55:225-76.

Harbone JB. Metode Fitokimia. Vol. 2. Bandung: Penerbit ITB; 1987. p. 49.

Tiedge M, Lenzen S. Effects of glucose refeeding and glibenclamide treatment on glucokinase and GLUT2 gene expression in pancreatic B-cells and liver from rats. Biochem J 1995;308:139-44.

Mujic A, Grdovic N, Mujic I, Mihailovic M, Zivkovic J, Poznanovic G, et al. Antioxidative effects of phenolic extracts from chestnut leaves, catkins and spiny burs in streptozotocin-treated rat pancreatic β-cells. Food Chem 2011;125:841-9.

Kabbaoui ME, Chda A, Mejrhit N, Azdad O, Farah A, Aarab L, et al. Antidiabetic effect of Thymus satureioides aqueous extract in streptozotocin-induced diabetic rats. Int J Pharm Pharm Sci 2016;8:140-5.

Bharathi TR, Prakash HS. Comparative evaluation of antidiabetic and antioxidant potency of different extracts obtained from Memecylon species. Int J Pharm Pharm Sci 2017;9:187-91.




About this article

Title

ANTIDIABETIC EFFECTS OF PUMPKIN (CUCURBITA MOSCHATA DURCH) FLESH AND SEEDS EXTRACTS IN STREPTOZOTOCIN INDUCED MICE

Topics

Biological Pharmacy

Keywords

Antidiabetic, Diabetes mellitus, Pumpkin, Streptozotocin, Mice.

DOI

10.22159/ajpcr.2018.v11i2.22023

Date

01-02-2018

Additional Links

Manuscript Submission

Journal

Asian Journal of Pharmaceutical and Clinical Research
Vol 11 Issue 2 February 2018 Page: 91-93

Print ISSN

0974-2441

Online ISSN

2455-3891

Authors & Affiliations

Novarianti Marbun
Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
Indonesia

Panal Sitorus
Department of Biological Pharmacy, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
Indonesia

Siti Morin Sinaga
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sumatera Utara, Medan, Indonesia.
Indonesia


Article Tools


Email this article (Login required)
Email the author (Login required)

Refbacks

  • There are currently no refbacks.