HYPOGLYCEMIC ACTIVITY OF ETHANOLIC EXTRACT OF SAURAUIA VULCANI KORTH. LEAVES

Authors

  • Panal Sitorus Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
  • Rosidah Rosidah Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia

DOI:

https://doi.org/10.22159/ajpcr.2018.v11s1.26561

Keywords:

Hypoglycemic, Saurauia vulcani Korth, Leaves, Extract, Ethanol

Abstract

 Objective: The aim of this study was to investigate the hypoglycemic activity of ethanol extract of Saurauia vulcani Korth. leaves.

Methods: S. vulcani Korth. leaf powder was extracted by maceration method with ethanol 96%. Hypoglycemic activity was examined on rats which is induced with streptozotocin 40 mg/Kg body weight (BW) at dose of 50; 100; and 200 mg/Kg BW.

Results: Hypoglycemic activity of the extract in diabetic rats showed a significant reduction in blood glucose levels (p<0.001) at dosage 50 mg/Kg BW.

Conclusion: The results reveal that ethanol extract of S. vulcani Korth. leaves has hypoglycemic activity. Our further study is to assess mechanism action as antidiabetic.

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Published

2018-04-26

How to Cite

Sitorus, P., R. Rosidah, and D. Satria. “HYPOGLYCEMIC ACTIVITY OF ETHANOLIC EXTRACT OF SAURAUIA VULCANI KORTH. LEAVES”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 13, Apr. 2018, pp. 35-36, doi:10.22159/ajpcr.2018.v11s1.26561.

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