• Dewi Safitri Institut Teknologi Bandung
  • Elin Yulinah Sukandar Institut Teknologi Bandung
  • Shafia Rachmamaryam Institut Teknologi Bandung


Aims: Kidneys are one of the vital organs which belong to the urinary system. Renal failure occurs when the kidneys are unable to perform excretory
functions which are important in maintaining homeostasis. Breadfruit leaves are commonly used empirically for the treatment of renal failure.
Objectives: This study aims to determine the influence of breadfruit leaves ethanol extract (BLEE) to improve renal function in the renal failure rat
Methods: Renal failure model was conducted by administering gentamicin 100 mg/kg body weight (bw) intraperitoneally for 7 days consecutively
and piroxicam 3.6 mg/kg bw for 5 weeks which was starting administered with gentamicin. BLEE were given for 4 weeks with dose of 50, 100, and
200 mg/kg bw, after gentamicin induction. Renal functions were evaluated by measuring urea and creatinine serum levels every week and renal
histology at the end of the experiment.
Results: After induction, urea and creatinine serum levels increased up to 5 times (p<0.05). Both parameters in all groups went up until the 2
and dropped on the 3
week. There was a significant difference in urea and creatinine serum levels in rats treated by BLEE 200 mg/kg. Histological
results depicted an improvement of the kidney structure. That treated by BLEE 200 mg/kg showed similarities appearance with the normal.
Conclusion: BLEE improved the kidney function in the renal failure model which was showed by reduction on the levels of serum urea and creatinine
and restore kidneys structure. BLEE 200 mg/kg bw showed better activity on ameliorating renal function.
Keywords: Renal failure, Serum urea, Serum creatinine, Breadfruit leaves, Gentamicin, Piroxicam.

Author Biographies

Dewi Safitri, Institut Teknologi Bandung
School of Pharmacy
Elin Yulinah Sukandar, Institut Teknologi Bandung
School of Pharmacy
Shafia Rachmamaryam, Institut Teknologi Bandung
School of Pharmacy


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How to Cite
Safitri, D., E. Y. Sukandar, and S. Rachmamaryam. “EFFECT OF ETHANOLIC EXTRACT OF BREADFRUIT (ARTOCARPUS ALTILIS [PARKINSON] FOSBERG) LEAVES ON AMELIORATING RENAL FUNCTION OF RAT”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 215-8, https://innovareacademics.in/journals/index.php/ajpcr/article/view/9594.
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