• Meti Widiya Lestari Tasikmalaya Polytechnic of Health-Ministry of Health
  • Andreanus A Soemardji
  • Irda Fidrianny


The aim of this review is to provide inspiration for research in  traditional use, pharmacological effects and toxicity of medicinal plants for women’s  health   in Indonesia. Punica granatum L, Coriandrum sativum L, Elephantopus scaber L, Foeniculum vulgare M, Kaempferia galanga L, Nigella sativa L are herbs often used as medicinal plants for women’s health care such as pregnancy’s disorders, leucorrhoea, menstrual disorders, aphrodisiac, natural contraception, care during childbirth, lactagogum, body and skin beauty care. The medicinal plants are often consumed directly or mixed in jamu/herbal medicine. Many research reported regarding the pharmacological effect and toxicity test of medicinal plants. This review will show the traditional use, pharmacological effect, and toxicity of Punica granatum, Coriandrum sativum, Elephantopus scaber, Foeniculum vulgare, Kaempferia galanga, Nigella sativa.

Keywords: Punica granatum, Coriandrum sativum, Elephantopus scaber, Foeniculum vulgare, Kaempferia galanga, Nigella sativa


1. Peri LM. Medicinal plant of East and Southeast Asia. The Mit Press. London; 1980.
2. Indonesian Pharmaceutical Association. List of natural medicine edition II. Indonesian Pharmaceutical Association Central Java. Semarang; 2001.
3. Ministry of Health of Indonesia. The utilization of medicinal plants for health of community. The Directorate General of Public Health Ministry of Health of Indonesia. Jakarta; 2010.
4. Van Hien HA. Het Javaansch recepten boek. Translated by: Bulhasrin. ITB, Bandung; 2003.
5. Cronquist A. An integrated system of classification of flowering plants. Columbia University Press, New York: 352; 1981.
6. Agency for Health Research and Development. Inventory Indonesian medicinal plants volume II. Ministry of Health of Indonesia. Jakarta; 2001.
7. Soeharso. Coriandrum sativum L. Asri. 63:98. Jakarta; 1988.
8. Sharma N, Sharma P, Jasuja ND, Joshi SC. Ameliorative efficiency of Coriandrum sativum seed extract on atherosclerosis and oxidative stress in male albino hyperlipidemic rabbits. Res J Pharm Biol Chem Sci 2014; 5(2): 26-39.
9. Seema M, Ankur S, Manjari V, Akanshi K, Parish A. Evaluation of antibacterial activity of methanol and acetone extracts of Trigonella foenum, Coriandrum sativum and Brassica nigra. Int J Drug Dev Res 2013; 5(3):316-21.
10. Tang ELH, Rajarajeswaran J, Fung SY, Kanthimathi MS. Antioxidant activity of Coriandrum sativum and protection against DNA damage and cancer cell migration. Complemen Alternat Med 2013; 13: 347.
11. Ramadan MM, Eldeen NN, El-Kamali HH, Ghanem KZ, Farrag ARH. Chemopreventive effect of Coriandrum sativum fruits on hepatic toxicity in male rats. World J Med Sci 2013; 8(4): 322-33.
12. Patel D, Desai S, Gajaria T, Devkar R, Ramachandran AV. Coriandrum sativum L. seed extract mitigates lipotoxicity in raw 264.7 cells and prevents atherogenic changes in rats. EXCLI J 2013; 12: 313-34.
13. Mazhar J, Mazumder A. Evaluation of antidiabetic activity of methanolic leaf extract of Coriandrum sativum in alloxan induced diabetic rats. Res J Pharm Biol Chem Sci 2013; 4(3): 500-7.
14. Nithya TG, Sumalatha D. Evaluation of invitro antioxidant and anticancer activity of Coriandrum sativum against human colon cancer HT- 29 cell lines. Int J Pharm Pharm Sci 2014; 6(2): 421-4.
15. Chithra V, Leelamma S. Hypolipidemic effect of coriander seeds (Coriandrum sativum): mechanism of action. Plant Foods Hum Nutr 1997; 51: 167–72.
16. Benelli G, Flamini G, Fiore G, Cioni PL, Conti B. Larvicidal and repellent activity of the essential oil of Coriandrum sativum L. (Apiaceae) fruits against the filariasis vector Aedes albopictus Skuse (Diptera: Culicidae). Parasitol Res 2013; 112: 1155–61.
17. Beikert FC, Anastasiadou Z, Fritzen B, Frank U, Augustin M. Topical treatment of tinea pedis using 6% coriander oil in Unguentum leniens: a randomized, controlled, comparative pilot study. Dermatology. 2013; 226: 47–51.
18. Patel D, Desai S, Devkar R, Ramachandran AV. Acute and sub-chronic toxicological evaluation of hydro-methanolic extract of Coriandrum sativum L seeds. EXCLI J 2012; 11: 566-75.
19. Al-Said MS, Al-Khamis KI, Islam MW, Parmar NS, Tariq M, Ageel AM. Post-coital antifertility activity of the seeds of Coriandrum sativum in rats. J Ethnopharmacol 1987; 21(2):165-73.
20. Wijayakusuma H, Dalimartha S, Wirian AS, Yaputra T. Medicinal plants in Indonesia. Pustaka Kartini; 1992.
21. Agency for Health Research and Development. Inventory Indonesian medicinal plants volume I. Ministry of Health of Indonesia. Jakarta; 2000.
22. Ho WY, Yeap SK, Ho CL, Rahim RA, Alitheen NB. Hepatoprotective activity of Elephantopus scaber on alcohol induced liver damage in mice. J Evidence-Based Comlementary Altern Med 2012; 2012: 1-8.
23. Hung HF, Hou CW, Chen YL, Lin CC. Elephantopus scaber inhibits lipopolysaccharide-induced liver injury by suppression of signaling pathways in rats. The Am J Chinese Med 2011; 39(4): 705–17.
24. Huang CC, Lo CP, Chiu CY, Shyur LF. Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumour growth and lung metastasis and doubles survival time in mice. Brit J Pharmacol 2010; 159: 856–71.
25. Geetha B S, Nair MS, Latha PG, Remani P. Sesquiterpene lactones isolated from Elephantopus scaber L. inhibits human lymphocyte proliferation and the growth of tumour cell lines and induces apoptosis in vitro. J Biomed Biotechnol 2012; 2012: 1-8.
26. Sagar R, Sahoo HB. Evaluation of antiasthmatic activity of ethanolic extract of Elephantopus scaber L. leaves. Indian J Pharmacol 2012; 44(3): 398-401.
27. Avani K, Neeta S. A study of the antimicrobial activity of Elephantopus scaber. Indian J Pharmacol 2005; 37(2): 126-7.
28. Singh S, Krishna V, Mankani K, Manjunatha B, Vidya S, Manohara Y. Wound healing activity of the leaf extracts and deoxyelephantopin isolated from Elephantopus scaber Linn. Indian J Pharmacol 2005; 37(4): 238-42.
29. Daisy P, Jasmine R, Ignacimuthu S, Murugan E. A novel steroid from Elephantopus scaber L. an ethnomedicinal plant with antidiabetic activity. Phytomedicine 2009; 16: 252–7.
30. Hiradeve SM, Rangari VD. Elephantopus scaber Linn.: A review on its ethnomedical, phytochemical and pharmacological profile. J App Biomed 2014; 12: 49-61.
31. Ho WY, Ky H, Yeap SK, Rahim RA, Omar AR, Ho CL, Alitheen NB. Traditional practice, bioactivities and commercialization potential of Elephantopus scaber Linn. J Med Plant Res 2009; 3(13): 1212-21.
32. Honarvar F, Tadayon M, Afshari P, Namjooyan F, Haghighi MH. The effect of Foeniculum vulgare on serum prolactin level in lactating women. Iran J Obs, Gynecol Infert 2013; 16(65): 18-24.
33. Josephine GI, Elizabeth AA, Muniappan M, Muthiah NS. Antidepressant activity of Foeniculum vulgare in forced swimming and tail suspension test. Res J Pharm Biol Chem Sci 2014; 5(2): 448-54.
34. Singh JN, Sunil K, Rana AC. Antidepressant activity of methanolic extract of Foeniculum vulgare (fennel) fruits in experimental animal models. J Appl Pharm Sci 2013; 3(9): 65-70.
35. Elizabeth AA, Josephine G, Muthiah NS, Muniappan M. Evaluation of analgesic and anti-inflammatory effect of Foeniculum vulgare. Res J Pharm Biol Chem Sci 2014; 5(2): 658-68.
36. Mohsenzadeh M. Evaluation of antibacterial activity of selected Iranian essential oils against Staphylococcus aureus and Escherichia coli in nutrient broth medium. Pak J Biol Sci 2007; 10: 3693–7.
37. Devika V, Mohandass S, Aiswary APR. Screening of methanolic extract of Foeniculum vulgare for hepatoprotective activity. Int J Pharm Pharm Sci 2013; 594: 56-9.
38. Al-Mohleh I, Al-Sobhaihani M, Alqasaumi S, Al-Said M, Al-Dosari M. Fennel Foeniculum vulgare treatment protect the gastric mucosa of rats against chemically induce histological lesion. Int J Pharmacol 2013; 9(3): 182-9.
39. Tanira MOM, Shah AH, Mohsin A, Ageel AM, Qureshi S. Pharmacological and toxicological investigations on Foeniculum vulgare dried fruit extract in experimental animals. Phytother Res 1996; 10(1): 33-6.
40. Ostad SN, Soodi M, Shariffzadeh M, Khorshidi N, Marzban H. The effect of fennel essential oil on uterine contraction as a model for dysmenorrhea, pharmacology and toxicology study. J Ethnopharmacol 2001; 76: 299–304.
41. Taylor JM, Jenner PM, Jones WI. A comparison of the toxicity of some allyl, propenyl, and propyl compounds in the rat. Toxicol App Pharmacol 1964; 6(4): 378–87.
42. Nauli RR. The effects of pomegranate (Punica granatum Linn) rind extract compared to ketoconazole 2% against the in vitro growth of Candida albicans in vulvovaginal candidiasis. Thesis, Diponegoro University. Semarang; 2010.
43. Amit K, Chaturvedi, Suaib L, Vijaya D, Jay PT, Dharmendra S, Chandan S, Chanotiya, Karuna S, Arvind SN. Inhibition of Cathepsin D protease activity by Punica granatum fruit peel extracts, isolates, and semisynthetic analogs. Med Chem Res 2013; 22: 3953–8.
44. Sugiarto NF. Antidiarrheal activity of extracts of Punica granatum L. Thesis. FMIPA Indonesia University, Jakarta; 2008.
45. Jiao M, Pharkphoom P, Kaewnopparat N, Anupong N, Reanmongkol W. Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract incomparison with its marker compound ellagic acid in vivo. J Ethnopharmacol 2013; 148: 901–8.
46. Jiao M, Pharkphoom P, Kaewnopparat N, Anupong N, Reanmongkol W. Wound healing activities of standardized pomegranate rind extract and its major antioxidant ellagic acid in rat dermal wounds. J Nat Med 2014; 68: 377–86.
47. Halvorsen BL, Holte K, Myhrstad MCW, Barikmo I, Hvattum E. A systematic screening of total antioxidants in dietary plan. J Nutr 2002; 132: 461-71.
48. Kaur G, Jabbar Z, Ahar M Alam MS. Punica granatum (pomegranate) flower extract possesses potent antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice. Food Chem Toxicol 2006; 44: 984-93.
49. Murthy KNC, Jayaprakasha GK, Singh RP. Studies on antioxidant activity of pomegranate (Punica granatum) peel extract using in vivo models. J Agric Food Chem 2002; 50: 4791-5.
50. Sudheesh S, Viayalakshmi NR. Flavonoids from Punica granatum potential antiperoxidaive agent. Fitoterapia 2005; 76: 181-6.
51. Gopalakrishnan S, Benny PJ. In vitro antimicrobial properties of Punica granatum extract on bacteria causing urinary tract infections. Indian Drugs 2009; 46: 17-22.
52. Zhang J, Zhang BY, Yao XJ. In vitro inactivation of hepatitis virus B (HBV) by promegranate rind and its clinical significance. Pharmacol Clin Chinese Materia Med 1997; 13: 29-31.
53. Haidari M, Ali M, Casscells SW, Madjid M. Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir. Phytomedicine 2009; 16: 1127-36.
54. Khalil EAM. Antidiabetic effect of an aqueous extract of promeganate (Punica granatum) peels in normal and alloxan diabetic rats. Egypt J Hosp Med 2004; 16: 92-99.
55. Zafar R, Singh J. Antidiabetic activity of Punica granatum Linn. Sci Culture 1990; 56: 3.
56. Rosenblat M, Volkova N, Coleman R, Aviram M. Pomegranate byproduct administration to apoliproteinE-deficient mice attenuates atherosceloris development as a result of decreased macrophage oxidative stress and reduce cellular uptake of oxidized low-density lipoprotein. J Agric Food Chem. 2006; 54: 1928-35.
57. Patel C, Dadhaniya P, Hingorani L, Soni MG. Safety assessment of pomegranate fruit extract: Acute and subchronic toxicity studies. Food Chem Toxicol 2008; 46: 2728–35.
58. Hasanah AN, Nazaruddin F, Febrina E, Zuhrotun A. Essential oil content analysis and anti-inflammatory activity of zeodary rhizome (Kaempferia galanga L.) extract. Math Sci J 2011; 16(3).
59. Umar MI, Asmawi MZ, Sadikun A, Atangwho IJ, Yam MF, Altaf R, Ahmed A. Bioactivity-guided isolation of ethyl-p-methoxycinnamate, an anti-inflammatory constituent, from Kaempferia galanga L. extracts. Molecules 2012; 17(7): 8720-34.
60. Umar MI, Asmawi MZ, Sadikun A, Majid AMSA, Al-Suede FSR, Hassan LEA, Altaf R, Ahamed MBK. Ethyl-p-methoxycinnamate isolated from Kaempferia galanga inhibits inflammation by suppressing interleukin- 1, tumor necrosis factor-α, and angiogenesis by blocking endothelial functions. Clinics 2014; 69(2): 134-44.
61. Vittalrao AM, Shanbhag T, Kumari K, Bairy KL, Shenoy S. Evaluation of antiinflammatory and analgesic activities of alcoholic extract of Kaempferia galanga in rats. Indian J Physiol Pharmacol 2011; 55(1): 13-24.
62. Manigaunha A, Ganesh N, Kharya MD. Hepatoprotection by Kaempferia galanga against carbon tetrachloride induced liver damage in rats. Indian Drugs 2010; 47(4): 55-60.
63. Choochote W, Kanjanapothi D, Panthong A, Taesotikul T, Jitpakdi A, Chaithong, U, Pitasawat B. Larvicidal, adulticidal and repellent effects of Kaempferia galanga. S. Asia J Trop Med Pub Health 1999; 30(3): 470-6.
64. Satoto TBT, Maniam S, Ganesen K, Ernaningsih. Larvicidal effect of ether and chloroform extract of Kaempferia galanga against the larvae of Aedes aegypti (Diptera: Culicidae). Int J Pharmacog Phytochem Res 2013; 5(2): 96-100.
65. Tara VS, Chandrakala S, Sachidananda A, Kurady BL, Smita S, Ganesh S. Wound healing activity of alcoholic extract of Kaempferia galanga in Wistar rats. Indian J Physiol Pharmacol 2006; 50(4): 384-90.
66. Kanjanapothi D, Panthong A, Lertprasertsuke N, Taesotikul T, Rujjanawate C, Kaewpinit D, Sudthayakorn R, Choochote W, Chaithong U, Jitpakdi A, Pitasawat B. Toxicity of crude rhizome extract of Kaempferia galanga L. J Ethnopharmacol 2004; 90(2-3): 359-65.
67. Ebru U, Burak U, Yusuf S, Reyhan B, Arif K, Faruk TH, Emin M, Aydın K, Atilla I, Semsettin S, Kemal E. Cardioprotective effects of Nigella sativa oil on cyclosporine a-induced cardiotoxicity in rats. Basic Clin Pharmacol Toxicol 2008; 103: 574–80.
68. Gani AMS, John SA. Evalution of hepatoprotective effect of Nigella sativa L. Int J Pharm Pharm Sci 2013; 5(4): 428-30.
69. Islam MH, Ahmad IZ, Salman MT. In vivo evaluation of anti-inflammatory and analgesic activities of Nigella sativa seed during germination. Int J of Pharm and Pharmaceut Sci 2013; 5(4): 451-4.
70. El-Dakhakhny M, Mady NI, Halim MA. Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittel-Forschung/Drug Res 2000; 50(9): 832-6.
71. Mahmoud SS, Torchilin VP. Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin. Cell Biochem Biophys 2012; 25(7): 1392-8.
72. Al-Othman A M, Ahmad F, Al-Orf S, Al-Murshed KS, Ariff Z. Effect of dietry supplementation of Ellataria cardamun and Nigella sativa on the toxicity of rancid corn oil in rats. Int J Pharmocol 2006; 2(1): 60-5.
73. Salama RH. Hypoglycemic effect of lipoic acid, carnitine and Nigella sativa in diabetic rat model. Int J Health Sci 2011; 5(2): 126-34.
74. Zaghlol DAA, Kamel EA, Mohammed DS, Abbas NA. The possible toxic effect of different doses of Nigella sativa oil on the histological structure of the liver and renal cortex of adult male albino rats. The Egypt J Histol 2011; 35: 127-36.
75. Tubesha Z, Imam MU, Mahmud R, Ismail M. Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in sprague dawley rats. Molecules 2013; 18(7): 7460-72.
76. Agarwal C, Narula A, Vyas DK, Jacob D. Effect of seeds of kalaunji on fertility and sialic acid content of the reproductive organs of male rat. Geo Bios 1990; 17: 269-72.
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How to Cite
Lestari, M. W., A. A. Soemardji, and I. Fidrianny. “REVIEW OF TRADITIONAL USE, PHARMACOLOGICAL EFFECTS AND TOXICITY OF MEDICINAL PLANTS FOR WOMEN’S HEALTH IN INDONESIA”. Asian Journal of Pharmaceutical and Clinical Research, Vol. 9, no. 1, Jan. 2016, pp. 41-46,
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