SOLID STATE CHARACTERIZATION OF A NOVEL PHYSICAL INTERACTION (PARACETAMOL-CHLORPHENIRAMINE MALEATE)


Iyan Sopyan, Intan Mutiara Sari, Insan Sunan K.

Abstract


Objective: Interactions of active pharmaceutical ingredients (API) as well as pharmaceutical excipients don’t occur in a pharmaceutical dosage form. Base on structures of paracetamol (PCT) and chlorphenamine maleate (CTM), its combination is possible to give a physical interaction in the solid state. This study was conducted to investigate the physical interaction of PCT and CTM in the solid state.

Methods: Characterization used the polarization microscope, solubility test, powder x-ray diffraction (PXRD) to observe peak shifting in 2Ɵ angle, and fourier transform infrared spectroscopy (FT-IR) to examine wavenumber shifting.

Results: Results of solubility exhibited an increased solubility percentage with increasing concentration. Polarization microscope analysis presented a combination of crystal morphology after the two substances were mixed in an equimolar ratio. The result of melting point determination of each pure substance was 172 °C for PCT, 132 °C for CTM, and 170 °C for the mixture of the two substances in various ratios. Diffractogram showed the shifting at angle 2Ɵ: 20.715, 19.355-23.500 and 21.840, 26.455-20.330 for concentration ratio of PCT: CTM in (132:0.5) and (330:1) respectively and any change in the functional group was observed from infrared spectrum.

Conclusion: All evaluation of PCT and CTM in the solid state has exhibited the interaction in solid condition.


Keywords


Paracetamol, Chlorphenamine maleate, Polarization microscope, X-Ray diffraction, FT-IR

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About this article

Title

SOLID STATE CHARACTERIZATION OF A NOVEL PHYSICAL INTERACTION (PARACETAMOL-CHLORPHENIRAMINE MALEATE)

Keywords

Paracetamol, Chlorphenamine maleate, Polarization microscope, X-Ray diffraction, FT-IR

DOI

10.22159/ijap.2018v10i1.22840

Date

06-01-2018

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol 10, Issue 1 (Jan-Feb), 2018 Page: 21-25

Online ISSN

0975-7058

Statistics

150 Views | 25 Downloads

Authors & Affiliations

Iyan Sopyan
Departement of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran
Indonesia

Intan Mutiara Sari
Departement of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran
Indonesia

Insan Sunan K.
Departement of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Universitas Padjadjaran
Indonesia


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