FORMULATION AND PHYSICAL STABILITY TEST OF GRISEOFULVIN MICROEMULSION GEL


Anindya Hana Iradhati, Mahdi Jufri

Abstract


Objective: The main objective of this research is to make and evaluate the formulation of a griseofulvin microemulsion gel for topical use to increase
the solubility and safety of the drug.
Methods: The optimized microemulsion formula contains 5% oleic acid as the oil phase, 25% Tween 80 as the surfactant, and 20% ethanol (96%)
as the cosurfactant.
Results: Organoleptic observations of the microemulsion showed that it had a clear and transparent yellowish color, while the microemulsion gel had
a hazy yellowish color. Both the microemulsion and the microemulsion gel had the smell of alcohol. The size of the globules in the microemulsion and
the microemulsion gel was 158.0 nm and 226.0, respectively.
Conclusions: The griseofulvin microemulsion gel was stable at 4°C±2°C, 25°C±2°C, and 40°C±2°C.


Keywords


Griseofulvin, Surfactant, Microemulsion gel, Physical stability, Formulation.

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References


International Agency for Research on Cancer. IARC Monographs

on the Evaluation of Carcinogenic Risks to Humans. Vol. 79. Lyon,

France: IARC Press; 2001. p. 75-89.

Tanaka Y, Waki R, Nagata S. Species differences in the dissolution

and absorption of griseofulvin and albendazole, biopharmaceutics

classification system class II drugs, in the gastrointestinal tract. Drug

Metab Pharmacokinet 2013;28(6):485-90.

Aggarwal N, Goindi S, Khurana R. Formulation, characterization and

evaluation of an optimized microemulsion formulation of griseofulvin

for topical application. Colloids Surf B Biointerfaces 2013;105:158-66.

Moghimipour E, Salimi A, Hassanvand S. Permeability assessment of

griseofulvin microemulsion through rat skin. Int J Pharm Chem Biol

Sci 2013;3(4):1061-5.

U.S. National Library of Medicine. Griseofulvin-Griseofulvin Tablet;

Available from: http://www.dailymed.nlm.nih.gov/dailymed/

drugInfo.cfm?setid=6149c044-58bb-402c-a4b5-18b96dd9b3b9. [Last

accessed on 2016 Jan 11].

Sinko PJ. Farmasi Fisika dan Ilmu Farmasetika. 5th ed. Jakarta: Buku

Kedokteran EGC; 2006.

Maya L. Pembuatan sediaan mikroemulsi dari minyak buah merah

(Pandanus conoideus). Skripsi. Depok: Universitas Indonesia; 2006.

Lachenmeier DW. Safety evaluation of topical applications of ethanol

on the skin and inside the oral cavity. J Occup Med Toxicol 2008;3:26.

Shinde U, Pokharkar S, Modani S. Design and evaluation of

microemulsion gel system of nadifloxacin. Indian J Pharm Sci

;74(3):237-47.

Kumar A, Kushwaha V, Sharma PK. Pharmaceutical microemulsion:

Formulation, characterization and drug deliveries across skin. Int J

Drug Dev Res 2014;6(1):1-21.

Júnior AA, Baldo JB. The behavior of zeta potential of silica

suspensions. N J Glass Ceram 2014;4:29-37.




About this article

Title

FORMULATION AND PHYSICAL STABILITY TEST OF GRISEOFULVIN MICROEMULSION GEL

Keywords

Griseofulvin, Surfactant, Microemulsion gel, Physical stability, Formulation.

DOI

10.22159/ijap.2017.v9s1.22_27

Date

30-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 23-27

Online ISSN

0975-7058

Statistics

19 Views | 34 Downloads

Authors & Affiliations

Anindya Hana Iradhati
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Mahdi Jufri
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia


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