FORMULATION OF NIOSOMAL GEL CONTAINING GREEN TEA EXTRACT (CAMELLIA SINENSIS L. KUNTZE) USING THIN-LAYER HYDRATION


Astrid Permatasari Isnan, Mahdi Jufri

Abstract


Objective: Green tea is known as a source of antioxidants. The most abundant of these is epigallocatechin gallate, which has been shown to modulate
biochemical pathways in the skin. Niosomes are an alternative to liposomal drug-vehicle systems, which have disadvantages such as cost and stability.
To overcome the problem of low permeation of active substances through skin layers and to increase their stability, a topical antioxidant preparation
based on niosomes was prepared.
Materials and Methods: To enhance drug stability, niosomal formulations were prepared in four different molar ratios of surfactant-to-cholesterol,
that is, 3:1 (F1), 2:1 (F2), 1:1 (F3), and 0.5:1 (F4). These were prepared using the thin-layer method. The niosomal suspensions were evaluated for
particle size and distribution, lamellarity, encapsulation efficiency, and zeta potential, and were then incorporated into gels using hydroxypropyl
methylcellulose as the gelling agent. The niosomal gels were evaluated for organoleptic properties, pH, viscosity, stability, and antioxidant activity
using 1,1-diphenyl-2-picrylhydrazyl.
Results: Results for the suspensions showed that F1 had the best encapsulation efficiency but experienced separation after 7 days.
Conclusions: Results for the niosomal gels (using F3) showed stable formulation without changes.


Keywords


Antioxidant activity, Encapsulation efficiency, Green tea extract, Niosome, stability.

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About this article

Title

FORMULATION OF NIOSOMAL GEL CONTAINING GREEN TEA EXTRACT (CAMELLIA SINENSIS L. KUNTZE) USING THIN-LAYER HYDRATION

Keywords

Antioxidant activity, Encapsulation efficiency, Green tea extract, Niosome, stability.

DOI

10.22159/ijap.2017.v9s1.23_28

Date

30-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 38-43

Online ISSN

0975-7058

Statistics

16 Views | 23 Downloads

Authors & Affiliations

Astrid Permatasari Isnan
Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Mahdi Jufri
Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia


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