THE EFFECTS OF MIXTURES OF VARIOUS CONCENTRATIONS OF CARBOXYMETHYL CHITOSAN/AMORPHOUS CALCIUM PHOSPHATE WITH GYPSUM ON DENTIN REMINERALIZATION

  • IKE DWI MAHARTI octoral Program, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • ENDANG SUPRASTIWI Department of Conservative Dentistry, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • HASTI DWI SETIATI Conservative Dentistry Residency Program, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • ERLIYANA YAMIN Conservative Dentistry Residency Program, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.
  • ANDI NURWALINI CAHYANI Conservative Dentistry Residency Program, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia.

Abstract

Objective: Carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) is a non-collagen protein analog with the ability of dentin
remineralization, and gypsum is a compound material than can facilitate application of CMC/ACP. CMC/ACP concentration is claimed to increase
calcium and phosphate concentration, which indicates dentin remineralization. The aim of this study is to observe the effects of different concentrations
of CMC/ACP mixed with gypsum on dentin remineralization.
Methods: Occlusal cavities were created in 18 freshly extracted teeth, and the teeth were divided into three groups. The first group consisted of
untreated demineralized dentin, and the second and third groups were treated with mixtures of 2.5% and 5% CMC/ACP and gypsum. All groups
were checked and analyzed on the 14th day using scanning electron microscopy/energy-dispersive X-ray spectroscopy and one-way ANOVA (p<0.05).
Results: Significant differences (p=0.001) of calcium and phosphate concentrations were found between Groups I, II, and III (p=0.001), whereas no
differences were found between Groups II and III.
Conclusion: Gypsum and CMC/ACP work synergistically to induce dentin remineralization. The highest dentin remineralization was shown by 5%
CMC/ACP-gypsum mixture, but the level was not statistically different from that of 2.5% CMC/ACP-gypsum mixture.

Keywords: Carboxymethyl chitosan, Amorphous calcium phosphate, Gypsum, Calcium sulfate, Remineralization

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MAHARTI, I. D., SUPRASTIWI, E., SETIATI, H. D., YAMIN, E., & CAHYANI, A. N. (2020). THE EFFECTS OF MIXTURES OF VARIOUS CONCENTRATIONS OF CARBOXYMETHYL CHITOSAN/AMORPHOUS CALCIUM PHOSPHATE WITH GYPSUM ON DENTIN REMINERALIZATION. International Journal of Applied Pharmaceutics, 12(2), 13-15. https://doi.org/10.22159/ijap.2020.v12s2.OP-15
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