EVALUATION OF TERATOGENICITY EFFECTS OF ETHANOLIC EXTRACTS OF BINAHONG LEAVES (ANREDERA CORDIFOLIA (TEN) STEENIS) IN WISTAR RAT

  • Elin Yulinah Sukandar Department of Pharmacology-Clinical Pharmacy, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia
  • Neng Fisheri Kurniati Department of Pharmacology-Clinical Pharmacy, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia
  • Via Fitria Department of Pharmacology-Clinical Pharmacy, School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia

Abstract

Objective: The aim of this study was to evaluate teratogenicity effect of ethanolic extract of binahong (Anredera cordifolia (Ten.) Steenis) leaves in Wistar rats.


Methods: The teratogenicity test were done in 5 groups of rat i. e. control group, trimethoprim at a dose of 360 mg/kg bw, ethanolic extract of binahong at doses of 100, 400, and 1000 mg/kg bw. Test substance was given orally on day 6 to day 15 of rats pregnancy. At day 20 of gestation, laparoctomy was performed to retrieve the fetuses. Evaluation was done towards the fetus skeletal, organ and fetal weight.


Results: Teratogenicity test results showed that there was the ungrowth fetus observed in all groups with the highest incident in trimethoprim group (39.5%). Average of fetus body weight of trimethoprim, control, binahong extract at doses of 100, 400 and 1000 mg/kg bw group was 2.32 ± 0.66 g, 3.58 ± 0.24 g, 3.64 ± 0.26 g, 3.67 ± 0.25 g and 3.93 ± 0.61 g, respectively. Skeletal evaluation showed that there was malformation of sacral vertebrae (65.2%), convulated costal stucture (82.6%), palate (33.3%), head cavity (88.9%), nasal cavity (5.6%), eye cavity (5.6%), ear (5.6%) and liver (43.1%) which were observed only in trimethoprim group.


Conclusion: Ethanolic extract of binahong at doses of 100, 400 and 1000 mg/kg bw in rat did not have the teratogenic effect.

Keywords: Binahong, Anredera cordifolia (Ten.) Steenis, Teratogenic effect, Trimethoprim.

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How to Cite
Sukandar, E. Y., N. F. Kurniati, and V. Fitria. “EVALUATION OF TERATOGENICITY EFFECTS OF ETHANOLIC EXTRACTS OF BINAHONG LEAVES (ANREDERA CORDIFOLIA (TEN) STEENIS) IN WISTAR RAT”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 6, no. 11, Nov. 2014, pp. 422-6, https://innovareacademics.in/journals/index.php/ijpps/article/view/3151.
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