HAVING A GO AT SPINAL MUSCULAR ATROPHY WITH SPINRAZA

Authors

  • Balaji O Department of Pharmacology, Kasturba Medical College, Manipal, Karnataka, India.
  • Amita D Department of Pharmacology, Kasturba Medical College, Manipal, Karnataka, India.
  • Sereen Rt Department of Pharmacology, Kasturba Medical College, Manipal, Karnataka, India.
  • Navin Ap Department of Pharmacology, Kasturba Medical College, Manipal, Karnataka, India.

DOI:

https://doi.org/10.22159/ajpcr.2017.v10i6.17502

Keywords:

Spinraza, Spinal muscualr atrophy, Antisense oligonucleotide, Adverse effects, Endear trial

Abstract

Spinal muscular atrophy (SMA), a neurological condition which is genetically mediated is the second most common infantile disease causing morbidity and mortality next to cystic fibrosis. It is of five different types with each type having different severity outcomes. For almost three decades, only supportive measures were advocated in the treatment of SMA. Recently, Biogen's Spinraza came out as the first disease modifying therapy to treat infantile as well as adult SMA. This review throws light on the pharmacological aspects of the drug; its approval by Food and Drug Administration and various completed clinical trials as well ongoing clinical trials.

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References

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Published

01-06-2017

How to Cite

O, B., A. D, S. Rt, and N. Ap. “HAVING A GO AT SPINAL MUSCULAR ATROPHY WITH SPINRAZA”. Asian Journal of Pharmaceutical and Clinical Research, vol. 10, no. 6, June 2017, pp. 16-18, doi:10.22159/ajpcr.2017.v10i6.17502.

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Review Article(s)

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