• Aminah Dalimunthe Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Indonesia.
  • Poppy Anjelisa Zaitun Hasibuan Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Indonesia.
  • Jansen Silalahi Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Indonesia.
  • Denny Satria Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Indonesia.



Antioxidant, Litsea cubeba, Fruits, Alkaloid, Fractions


 Objective: The oxidation induced by free radicals results in many degenerative disease. The purpose of this study is to determine antioxidant activities of alkaloid fractions of Litsea cubeba (Lour.) fruit.

Methods: L. cubeba Lour. was extracted by maceration. Ethanol extract was fractionated with liquid-liquid extraction using n-hexane and chloroform at pH 3, 7, 9, and 11 to obtained alkaloid fractions. Antioxidant activity for extract and fractions was determined with 1,1-diphenyl-2-picrylhydrazyl.

Results: The IC50 of extract and fractions was 219.43±0.43, 242.97±0.93, 92.38±0.17, 40.84±0.04, 103.83±3.29, and 103.75±0.42 μg/mL, respectively.

Conclusion: The results reveal that alkaloid fractions of L. cubeba fruits have very strong antioxidant potential. Our further study is to isolate the alkaloid compounds.


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How to Cite

Dalimunthe, A., P. A. Zaitun Hasibuan, J. Silalahi, and D. Satria. “ANTIOXIDANT ACTIVITY OF ALKALOID FRACTIONS OF LITSEA CUBEBA LOUR. FRUITS”. Asian Journal of Pharmaceutical and Clinical Research, vol. 11, no. 13, Apr. 2018, pp. 31-32, doi:10.22159/ajpcr.2018.v11s1.26558.



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