IDENTIFICATION AND ANALYSIS OF DRUG-RELATED PROBLEMS INCIDENCE AT HOSPITALIZED PATIENTS IN HAJI REGIONAL GENERAL HOSPITAL, MAKASSAR
Objective: This study aims to identify inpatient medication problems and analyze the association between patient characteristics and the incidence of the drug-related problem (DRP) experienced by patients.
Methods: The cross-sectional study was conducted at Haji Regional General Hospital, Makassar, using medical record data for inpatients from January to February 2020. Data were collected from September to October 2020. A total of 247 inpatients were identified using the Indonesian version of the Pharmaceutical Care Network Europe.
Results: The most common DRP problem found is the effect of drug treatment not optimal (P1.2) by 35.76% and the most common cause found is no or incomplete drug treatment despite existing indication (C1.6) by 20.16%. Bivariate analysis shows that age, length of stay, and the number of drugs received are significant different with the incidence of DRP in patients (p < 0,01) respectively. Multivariate analysis using logistic regression shows that age, sex, and the number of drugs could significantly affect the incidence of DRP (p<0.05) with the r-square (R2) of 21.6%. According to this model, the largest odds ratio number and the most likely to experience DRP in a patient are age, the number of drugs, then gender (5,2; 4,6; and 2,3).
Conclusion: Age, length of stay, and the number of drugs received affect the DRP incidence in a patient, while gender together with age and the number of drugs affecting the incidence of DRP in a patient.
2. Rikomah SE. Farmasi Klinik. Yogyakarta: Deepublish Publisher; 2016.
3. Al-Azzam SI, Alzoubi KH, Alefan Q, Alzayadeen RN. Evaluation of the types and frequency of DRP and the association with gender in patients with chronic diseases attending a primary health care center in Jordan. Int Health 2016;8:423-6.
4. Abu Farha RK, Mukattash TL, Qudah R, Alkhalaileh W, Alsaffar S. DRP and health-related quality of life in outpatients with Type 2 diabetes: A cross-sectional study from Jordan. J Pharm Health Serv Res 2019;10:303-9.
5. Hsu KL, Fink JC, Ginsberg JS, Yoffe M, Zhan M, Fink W, et al. Self-reported medication adherence and adverse patient safety events in CKD. Am J Kidney Dis 2015;66:621-9.
6. Kova?evi? SV, Miljkovi? B, ?ulafi? M, Kova?evi? M, Golubovi? B, Jovanovi? M, et al. Evaluation of DRPin older polypharmacy primary care patients. J Eval Clin Pract 2017;23:860-5.
7. Ramadaniati HU, Anggriani Y, Wowor VM, Rianti A. DRPin chronic kidneys disease patients in an Indonesian hospital: Do the problems really matter? Int J Pharm Pharm Sci 2016;8:298-302.
8. Zazuli Z, Rohaya A, Adnyana KI. DRPin Type 2 diabetic patients with hypertension: A prospective study. Int J Green Pharm 2017;11:298-304.
9. Sagita VA, Bahtiar A, Andrajati R. Evaluation of a clinical pharmacist intervention on clinical and DRP among coronary heart disease inpatients: A pre-experimental prospective study at a general hospital in Indonesia. Sultan Qaboos Univ Med J 2018;18:e81-7.
10. Dahlan, S. Statistik Untuk Kedokteran dan Kesehatan. 6th ed. Jakarta: Epidemiologi Indonesia; 2014.
11. Herman MJ, Sari ID. Analisis MTO di lima rumah sakit tahun 2010. J Ilmu Kefarmasian Indones 2012;10:163-9.
12. Saldanha V, Martins RR, Lima SI, de Araujo IB, Oliveira AG. Incidence, types and acceptability of pharmaceutical interventions about drug related problems in a general hospital: an open prospective cohort. BMJ Open 2020;10:1-8.
13. Abunahlah N, Elawaisi A, Velibeyoglu FM, Sancar M. Drug related problems identified by clinical pharmacist at the internal medicine ward in Turkey. Int J Clin Pharm 2018;40:360-7.
14. Lenssen R, Heidenreich A, Schulz JB, Trautwein C, Fitzner C, Jaehde U, et al. Analysis of DRPin three departments of a German University hospital. Int J Clin Pharm 2016;38:119-26.
15. Modesto AC, Ribeiro AM, Pereira JL, Silva LT, Provin MP, Ferreira PS, et al. Evaluation of a method for DRP identification and classification in hospital setting: Applicability and reliability. Int J Clin Pharm 2020;42:193-200.
16. Peterson C, Gustafsson M. Characterisation of DRP and Associated factors at a clinical pharmacist service-naïve hospital in Northern Sweden. Drugs Real World Outcomes 2017;4:97-107.
This work is licensed under a Creative Commons Attribution 4.0 International License.
The publication is licensed under CC By and is open access. Copyright is with author and allowed to retain publishing rights without restrictions.