FORMULATION OF A FAST-DISINTEGRATING TABLET USING MALTODEXTRIN DE 10-15 AND PREGELATINIZATED CASSAVA STARCH AS EXPEDIENTS


Ahmad Zaki, Effionora Anwa, Silvia Surini

Abstract


Objective: Fast-disintegrating tablets are a pharmaceutical preparation that is rapidly being developed because they can dissolve in the oral cavity
without chewing and without additional water support. The type of dissolver is a crucial component in fast-disintegrating tablets. Maltodextrin and
pregelatinized cassava starch (PPS) are excipients that can be used as dissolvers. This study aimed to formulate fast-disintegrating tablets using a
combination of maltodextrin dextrose equivalent (DE) 10-15 and PPS in various concentrations as excipients.
Methods: The cassava starch classified as PPS was obtained. PPS was then mixed with maltodextrin DE 10-15 to create fast-disintegrating tablets
using the wet granulation method.
Results: Tablet evaluation showed that formula F containing 40% maltodextrin DE 10-15 and 10% PPS was the most effective of the proposed fastdisintegrating
tablets.
Conclusions: Formula F has a hardness of 3.39 kp, 0.74% friability, a wetting time of 7.87 seconds, and a dissolve time of 38.55 seconds.


Keywords


Maltodextrin dextrose equivalent 10-15, Fast-disintegrating tablets, Pregelatinized cassava starch.

| PDF |

References


Fu Y, Yang S, Jeong SH, Kimura S, Park K. Orally Fast disintegrating

tablets: Developments, technologies, taste-masking and clinical studies.

Purdue university, departments of pharmaceutics and biomedical

engineering, West Lafayette, Indiana, USA. Crit Rev Ther Drug Carrier

Syst 2007;21(6):433-75.

Bhowmik D, Chiranjib B, Krishnakanth P, Chandira RM. Fast

dissolving tablet: An overview. J Chem Pharm Res 2009;1(1):163-77.

Kennedy JF, Knill CJ, Taylor DW. Maltodextrin. Dalam. In:

Kearsley MW. Dziedzic SZ, editors. Handbook of Starch Hydrolisis

Products and Their Derivatives. London: Blackie Academy dan

Professional; 1995. p. 65-76.

Bertolini AC. Starches: Characterization, Properties, and Applications.

New York: CRC Press; 2010. p. 1-2, 166-7.

Wade A. dan Weller PJ. Handbook of Pharmaceutical Excipient. 6th ed.

London: The Pharmaceutical Press; 2009. p. 442-4, 731-3.

Anwar E, Djajadisastra J, Yanuar A, Bahtiar A. Pemanfaatan

maltodekstrin pati terigu sebagai eksipien dalam formula sediaan tablet

dan niosom. Majalah Ilmu Kefarmasian 2004;1(1):34-6.

Gonnissen Y, Remon JP, Vervaet C. Effect of maltodextrin and

superdisintegrant in directly compressible powder mixtures prepared

via co-spray drying. Eur J Pharm Biopharm 2008;68(2):277-82.

Rachmawati AL. Pemanfaatan Pregel Pati Singkong Suksinat Sebagai

Eksipien Dalam Pembuatan Tablet Cepat Hancur. Depok: Skripsi

Sarjana FMIPA UI; 2007. p. 45.

Departemen Kesehatan Republik Indonesia. Farmakope Indonesia

edisi III. Jakarta: Departemen Kesehatan RI; 1979. p. 6-7.

Abu-Izza KA, Li VH, Look JL, Parr GD, Schineller MK. A review on

recent patents on fast dissolving drug delivery system. Int J PharmTech

Res 2009;1(3):790-8.

Lachman L, Lieberman HA, Kanig JL. The Theory and Practice of

Industrial Pharmacy. 2nd ed. Philadelphia: Lea dan Febiger; 1986.

p. 139-64, 648-705.

Rawas-Qalaji MM, Simons FE, Simons KJ. Fast-disintegrating

sublingual tablet: Effect of epinephrine load on tablet characteristics.

AAPS Pharm Sci Tech 2006:7(2):E41.

Takahashi R, Ojima T. Pregelatinization of wheat starch in a drum drier.

In: Bertolini, Andrea C, editors. Starches: Characterization, Properties,

and Applications. New York: CRC Press; 2010. p. 167.




About this article

Title

FORMULATION OF A FAST-DISINTEGRATING TABLET USING MALTODEXTRIN DE 10-15 AND PREGELATINIZATED CASSAVA STARCH AS EXPEDIENTS

Keywords

Maltodextrin dextrose equivalent 10-15, Fast-disintegrating tablets, Pregelatinized cassava starch.

DOI

10.22159/ijap.2017.v9s1.40_46

Date

30-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 71-73

Online ISSN

0975-7058

Statistics

23 Views | 30 Downloads

Authors & Affiliations

Ahmad Zaki
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Effionora Anwa
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Silvia Surini
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia


Refbacks

  • There are currently no refbacks.