ENZYMATIC DEGRADATION OF CROSS-LINKED EXCIPIENT MATRIX OF CO-PROCESSED XANTHAN GUM-AMYLOSE AND DISSOLUTION PROFILE OF DICLOFENAC SODIUM TABLET


Silvia Surini, Nurul Nizma, Azizahwati Azizahwati

Abstract


Objectives: This study aims to determine the amount of excipient that is degraded by alpha-amylase and the influence of alpha-amylase to the
dissolution profile of sustained-release tablets that use matrix CL-Co-A-XG.
Methods: Excipient is cross-linked with two concentrations of sodium trimetaphospate, which are 6% (CL6-Co-A-XG) and 12% (CL12-Co-A-XG).
Each excipient is made with the ratios 1:1, 1:2, and 2:1 amylose-xanthan gum. Enzymatic degradation tests are performed on excipient powders for
60 minutes. Sustained-release tablet with CL-Co-A-XG excipient as a matrix is formulated through direct compression method. Then, drug dissolution
tests are performed in a phosphate buffer with a pH of 7.4 both using and without using alpha-amylase as a medium for 8 hrs.
Results: The results of this study show that CL6-Co-A-XG and CL12-Co-A-XG degraded 20% at 10 and 30 minutes, respectively. In addition, the release
profile of F1-F6 tablets show the sustained-release profile that follows zero-order and Korsmeyer–Peppas kinetics and is unaffected by the presence
of alpha-amylase.
Conclusions: From this study, it can be concluded that the CL-Ko-A-XG excipients are more resistant to enzymatic degradation than amylose. Therefore,
this excipient shows potential as a single matrix sustained-release tablet.


Keywords


Cross-linked of excipient co-processed xanthan gum-amylose, Alpha-amylase, Dissolution profile, Enzymatic degradation, Sustained-release tablet.

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About this article

Title

ENZYMATIC DEGRADATION OF CROSS-LINKED EXCIPIENT MATRIX OF CO-PROCESSED XANTHAN GUM-AMYLOSE AND DISSOLUTION PROFILE OF DICLOFENAC SODIUM TABLET

Keywords

Cross-linked of excipient co-processed xanthan gum-amylose, Alpha-amylase, Dissolution profile, Enzymatic degradation, Sustained-release tablet.

DOI

10.22159/ijap.2017.v9s1.42_48

Date

30-10-2017

Additional Links

Manuscript Submission

Journal

International Journal of Applied Pharmaceutics
Vol. 9, Special Issue (Oct.), 2017 [PTMDS 2017] Page: 77-84

Online ISSN

0975-7058

Statistics

17 Views | 22 Downloads

Authors & Affiliations

Silvia Surini
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Nurul Nizma
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia

Azizahwati Azizahwati
Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.
Indonesia


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