OPTIMIZATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS OF LEMONGRASS (CYMBOPOGON CITRATUS) ESSENTIAL OIL


Tri Ujilestari, Bambang Ariyadi, Ronny Martien, Zuprizal ., Nanung Danar Dono

Abstract


Objective: Focus of this study was to optimize and to characterize the self-nanoemulsifying drug delivery system using lemongrass (Cymbopogon citratus) essential oil.

Methods: The optimum formulas were analyzed using a D-Optimal mixture experimental design and performed using a Design Expert® Ver. 7.1.5. Formulation variables which include in the design were: oil component X1 (a mixture of Cymbopogon citratus essential oil and virgin coconut oil/VCO), surfactant X2 (Tween 80), and co-surfactant (PEG 400), while emulsification time in a sec (Y1) and transmittance in percent (Y2) as responses.

Results: The optimum formula for SNEDDS in the current study were: Cymbopogon citratus essential oil (7.147%), VCO (7.147%), Tween 80 (71.417%), and PEG 400 (14.290%). From the optimizing formula can be shown that the mean of droplet size, polydispersity-index, zeta potential, and viscosity were: 13.17 ± 0.06 nm, 0.17 ± 0.05, -20.90 ± 1.47 mV, 200 ± 0mPa.s (n=3), respectively. Furthermore, the optimized formula has passed the thermodynamic stability test, meanwhile transmission electron microscopy displayed spherical shape.

Conclusion: The optimized SNEDDS formula was improving solubility of poorly soluble Cymbopogon citratus essential oil.


Keywords


Cymbopogon citratus, D-optimal mixture design, optimization, self-nanoemulsifying drug delivery system (SNEDDS)

References


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