OPTIMIZATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS OF LEMONGRASS (CYMBOPOGON CITRATUS) ESSENTIAL OIL

  • Tri Ujilestari Department of Animal Nutrition and Feed Science, Faculty of Animal Science, Universitas Gadjah Mada, Yogyakarta, Indonesia
  • Bambang Ariyadi Department of Animal Production, Faculty of Animal Science, Universitas Gadjah Mada, Yogyakarta, Indonesia
  • Ronny Martien Department of Pharmaceutics, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
  • Zuprizal . Department of Animal Nutrition and Feed Science, Faculty of Animal Science, Universitas Gadjah Mada, Yogyakarta, Indonesia
  • Nanung Danar Dono Department of Animal Nutrition and Feed Science, Faculty of Animal Science, Universitas Gadjah Mada, Yogyakarta, Indonesia

Abstract

Objective: Focus of this study was to optimize and to characterize the self-Nano emulsifying drug delivery system using lemongrass (Cymbopogon citratus) essential oil.

Methods: The optimum formulas were analyzed using a D-Optimal mixture experimental design and performed using a Design Expert® Ver. 7.1.5. Formulation variables which include in the design were: oil component X1 (a mixture of Cymbopogon citratus essential oil and virgin coconut oil/VCO), surfactant X2 (Tween 80), and co-surfactant (PEG 400), while emulsification time in a sec (Y1) and transmittance in percent (Y2) as responses.

Results: The optimum formula for SNEDDS in the current study were: Cymbopogon citratus essential oil (7.147%), VCO (7.147%), Tween 80 (71.417%), and PEG 400 (14.290%). From the optimizing formula can be shown that the mean of droplet size, polydispersity-index, zeta potential, and viscosity were: 13.17±0.06 nm, 0.17±0.05,-20.90±1.47 mV, 200±0mPa. s (n=3), respectively. Furthermore, the optimized formula has passed the thermodynamic stability test; meanwhile, transmission electron microscopy displayed spherical shape.

Conclusion: The optimized SNEDDS formula was improving solubility of poorly soluble Cymbopogon citratus essential oil.

Keywords: Cymbopogon citratus, D-optimal mixture design, optimization, self-nanoemulsifying drug delivery system (SNEDDS)

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Ujilestari, T., Ariyadi, B., Martien, R., ., Z., & Dono, N. (2019). OPTIMIZATION OF SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEMS OF LEMONGRASS (CYMBOPOGON CITRATUS) ESSENTIAL OIL. International Journal of Applied Pharmaceutics, 11(1), 144-149. https://doi.org/10.22159/ijap.2019v11i1.30099
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