FORMULATION OF MUCOADHESIVE BUCCAL FILMS USING PREGELATINIZED CASSAVA STARCH PHTHALATE AS A FILM-FORMING POLYMER

  • Silvia Surini Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424,
  • Fungi Gotalia Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424,
  • Kurnia Sari Setio Putri Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424,

Abstract

Objective: This study aimed to compare the characteristics of four buccal films formulated with phthalylated cassava starch and their drug delivery
potentials.
Methods: An alternative to conventional (oral) drug administration is to administer drugs in a buccal film; however, the required dosage must
be dissolved in a film-forming polymer with suitable mechanical and mucoadhesive characteristics. Previous studies have produced excipients
by physically and chemically modifying starch, such as by completely pregelatinization and phthalylation it in an aqueous medium under alkaline
conditions (pH 8–10). This produced a pregelatinized cassava starch phthalate (PCSPh) powder with a high degree of substitution (0.0541±0.0019),
thus giving it different physical, chemical, and functional characteristics than unphthalated PCS.
Results: PCSPh in 4.5% and 6% (w/w) concentrations was used as excipients for producing four formulations of buccal film. One film had the
most suitable characteristics, with an ex vivo mucoadhesion time of 57.1±20.3 min, tensile strength of 0.84±0.02 N/mm2, and a more rapid drug
release profile than two of the other film types produced. Our tests also revealed that the best film tended to not change physically when moistened
(percentage moisture absorption was 139% and moisture loss was 65%).
Conclusion: Thus, we predict that PCSPh could be adequately formulated to provide mucoadhesive buccal films with an appropriate drug release profile.

Keywords: Buccal film, Film-forming polymer, Modification of starch, Mucoadhesive, Pregelatinized cassava starch phthalate.

References

1. Bukka R, Prakasam K. Evaluation of cellulose polymers for buccal film
formulation of rasagiline. Asian J Pharm Clin Res 2014;7:83-7.
2. Mishra SP, Dixit GR, Chavan JI, Kanchan P. Formulation and
characterization of mucoadhesive buccal film of ranitidine
hydrochloride using Sterculia foetida gum as polymer. Asian J Pharm
Clin Res 2015;8:68-71.
3. Repka MA, Chen L, Chan RS. Buccal drug delivery. In: Clive GW,
Patrick JC, editors. Controlled Release in Oral Drug Delivery.
New York: Springer Science Business Media; 2011. p. 329-59.
4. Putri KS, Surini S, Anwar E. Pregelatinized cassava starch phthalate
as film-forming excipient for transdermal film of ketoprofen. Asian J
Pharm Clin Res 2013;6:62-6.
5. Moffat AC, Osselton MD, Widdop B. Clarke’s Analysis of Drugs and
Poisons. London: The Pharmaceutical Press; 2005.
6. Lala R, Thorat AA, Gargote CS, Awari NG. Preparation of
buccoadhesive polymeric film of ketoprofen and its evaluation. Asian J
Pharm Sci 2011;6:267-74.
7. Bottenberg P, Cleymaet R, de Muynck C, Remon JP, Coomans D,
Michotte Y, et al. Development and testing of bioadhesive, fluoridecontaining
slow-release tablets for oral use. J Pharm Pharm
1991;43:457-64.
8. Semalty M, Semalty A, Kumar G. Formulation and characterization
of mucoadhesive buccal films of glipizide. Indian J Pharm Sci
2008;70:43‑8.
9. Mohamed MI, Haider M, Ali MA. Buccal mucoadhesive films
containing antihypertensive drug: In vitro/in vivo evaluation. J Chem
Pharm Res 2008;3:665-86.
10. Mathew AP, Dufresne A. Plasticized waxy maize starch: Effect of polyols
and relative humidity on material properties. Biomacromolecules
2002;3:1101-8.
11. Lieberman ER, Guilbert SG. Gas permeation of collagen films as
affected by cross-linkage, moisture, and plasticizer content. J Polym
Sci 1973;41:33-3.
12. Boonsong P, Laohakunjit N, Kerdchoechuen O, Tusvil P. Properties and
permeability of aroma compounds in food through plasticized cassava
films. Int Food Res J 2009;16:97-103.
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Surini, S., Gotalia, F., & Putri, K. S. S. (2018). FORMULATION OF MUCOADHESIVE BUCCAL FILMS USING PREGELATINIZED CASSAVA STARCH PHTHALATE AS A FILM-FORMING POLYMER. International Journal of Applied Pharmaceutics, 10(1), 225-229. https://doi.org/10.22159/ijap.2018.v10s1.50
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