• Effionora Anwar Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Dyah Ayu Ratna Yulianti Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia
  • Kurnia Sari Setio Putri Department of Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia


Objective: This study aimed to determine the stability of microspheres of Sargassum plagyophyllum (brown seaweed) after preparation using spray
drying with maltodextrin DE 10–15 and during drying and storage.
Methods: Aqueous extracts of brown seaweed were formulated into microspheres using maltodextrin DE 10–15 as a coating agent. For increasing the
stability of polyphenol compounds, spray drying was performed with an inlet temperature of 110°C. Four microsphere formulations were produced
using maltodextrin DE 10–15 at concentrations of 0%, 5%, 10%, and 15%. The resulting microspheres were then characterized in the assessments of
moisture contents, particle size distributions, pH, total phlorotannin contents, and antioxidant activity, and surface morphology was analyzed using
scanning electron microscope analyses.
Results: Powders that were produced with 0% and 15% maltodextrin were more stable at 4°C±2°C than at 28°C±2°C and 40°C±2°C. At the lowest
temperature, phlorotannin contents were maintained in powders that were prepared with 15% maltodextrin but were decreased by 10% in powders
that were prepared without maltodextrin.
Conclusion: Maltodextrin DE 10–15 is a suitable coating agent for dry formulations of S. plagyophyllum powder and maintained stability during spray
drying at 110°C and during storage for 2 months at 4°C±2°C.

Keywords: Maltodextrin, Microsphere, Phlorotannin, Sargassum plagyophyllum, Spray drying.


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How to Cite
Anwar, E., Yulianti, D. A. R., & Putri, K. S. S. (2018). STABILITY OF MICROSPHERE OF SARGASSUM PLAGYOPHYLLUM (MERTENS) J. G. AGARDH EXTRACT PRODUCED BY SPRAY DRYING USING MALTODEXTRIN. International Journal of Applied Pharmaceutics, 10(1), 376-380.
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